Progesterone-modified natural cycle preparation for frozen embryo transfer.

Autor: Kornilov N; Centre for Reproductive Medicine, Co. Ltd., Next Generation Clinic, St Petersburg, Russia; Centre for Reproductive Medicine, Co. Ltd., Next Generation Clinic, Moscow, Russia., Polyakov A; University of Melbourne, Faculty of Medicine and Health Sciences, Parkville, Victoria, Australia; Reproductive Biology Unit, Royal Women's Hospital, Melbourne, Victoria, Australia., Mungalova A; Centre for Reproductive Medicine, Co. Ltd., Next Generation Clinic, St Petersburg, Russia., Yakovleva L; Federal State Budgetary Educational Institution of Higher Education, Mari State University, Russia., Yakovlev P; Centre for Reproductive Medicine, Co. Ltd., Next Generation Clinic, Moscow, Russia. Electronic address: iakovlevpp@gmail.com.
Jazyk: angličtina
Zdroj: Reproductive biomedicine online [Reprod Biomed Online] 2024 Nov; Vol. 49 (5), pp. 104350. Date of Electronic Publication: 2024 Jul 02.
DOI: 10.1016/j.rbmo.2024.104350
Abstrakt: Research Question: Is there any difference in clinical outcomes between the progesterone-modified natural cycle (P4mNC) and hormone replacement therapy (HRT) endometrial preparation protocols after single euploid blastocyst frozen embryo transfer (FET) cycles?
Design: A retrospective cohort study was performed at a single, private, high-volume fertility centre. Patients who underwent single euploid blastocyst FET between January 2017 and December 2019 were included. A total of 1933 FET cycles were reviewed, and 723 FET cycles from 548 patients met the inclusion criteria. Two groups were compared according to endometrial preparation: 327 P4mNC-FET and 396 HRT-FET cycles. The primary outcome was the live birth rate. The secondary outcomes included the clinical pregnancy rate and the miscarriage rate.
Results: There were no differences in the clinical pregnancy rate (50.2% versus 47.0%, P = 0.688), miscarriage rate (9.8% versus 14.5%, P = 0.115) and live birth rate (45.0% versus 39.6%, P = 0.331) between the P4mNC-FET and HRT-FET groups after covariate adjustments.
Conclusions: There were no differences in the clinical outcomes between the P4mNC-FET and HRT-FET cycles. These results indicate that P4mNC-FET cycles produce clinical outcomes comparable to those of more traditional HRT-FET while allowing greater flexibility in the timing of embryo transfer.
(Copyright © 2024 The Author(s). Published by Elsevier Ltd.. All rights reserved.)
Databáze: MEDLINE
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