Targeting cell death in NAFLD: mechanisms and targeted therapies.

Autor: Xu HL; Department of Endocrinology and Metabolism, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, PR China.; Metabolic Vascular Disease Key Laboratory of Sichuan Province, Luzhou, Sichuan, PR China.; Sichuan Clinical Research Center for Nephropathy, Luzhou, Sichuan, PR China., Wan SR; Department of Endocrinology and Metabolism, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, PR China.; Metabolic Vascular Disease Key Laboratory of Sichuan Province, Luzhou, Sichuan, PR China.; Sichuan Clinical Research Center for Nephropathy, Luzhou, Sichuan, PR China., An Y; Department of Endocrinology and Metabolism, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, PR China.; Metabolic Vascular Disease Key Laboratory of Sichuan Province, Luzhou, Sichuan, PR China.; Sichuan Clinical Research Center for Nephropathy, Luzhou, Sichuan, PR China., Wu Q; Department of Endocrinology and Metabolism, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, PR China.; Metabolic Vascular Disease Key Laboratory of Sichuan Province, Luzhou, Sichuan, PR China.; Sichuan Clinical Research Center for Nephropathy, Luzhou, Sichuan, PR China.; Department of Pathology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, PR China.; Precision Pathology Diagnosis for Serious Diseases Key Laboratory of LuZhou, Luzhou, Sichuan, PR China., Xing YH; Department of Endocrinology and Metabolism, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, PR China.; Metabolic Vascular Disease Key Laboratory of Sichuan Province, Luzhou, Sichuan, PR China.; Sichuan Clinical Research Center for Nephropathy, Luzhou, Sichuan, PR China., Deng CH; Department of Endocrinology and Metabolism, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, PR China.; Metabolic Vascular Disease Key Laboratory of Sichuan Province, Luzhou, Sichuan, PR China.; Sichuan Clinical Research Center for Nephropathy, Luzhou, Sichuan, PR China., Zhang PP; Department of Endocrinology and Metabolism, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, PR China.; Metabolic Vascular Disease Key Laboratory of Sichuan Province, Luzhou, Sichuan, PR China.; Sichuan Clinical Research Center for Nephropathy, Luzhou, Sichuan, PR China.; Department of Pathology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, PR China.; Precision Pathology Diagnosis for Serious Diseases Key Laboratory of LuZhou, Luzhou, Sichuan, PR China., Long Y; Department of Endocrinology and Metabolism, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, PR China.; Metabolic Vascular Disease Key Laboratory of Sichuan Province, Luzhou, Sichuan, PR China.; Sichuan Clinical Research Center for Nephropathy, Luzhou, Sichuan, PR China., Xu BT; The People's Hospital of Pingyang, Wenzhou, Zhejiang, PR China. xu651044138@163.com., Jiang ZZ; Department of Endocrinology and Metabolism, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, PR China. jiangzongzhe555@swmu.edu.cn.; Metabolic Vascular Disease Key Laboratory of Sichuan Province, Luzhou, Sichuan, PR China. jiangzongzhe555@swmu.edu.cn.; Sichuan Clinical Research Center for Nephropathy, Luzhou, Sichuan, PR China. jiangzongzhe555@swmu.edu.cn.; Academician (Expert) Workstation of Sichuan Province, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, PR China. jiangzongzhe555@swmu.edu.cn.
Jazyk: angličtina
Zdroj: Cell death discovery [Cell Death Discov] 2024 Sep 07; Vol. 10 (1), pp. 399. Date of Electronic Publication: 2024 Sep 07.
DOI: 10.1038/s41420-024-02168-z
Abstrakt: Nonalcoholic fatty liver disease (NAFLD) is a group of chronic liver disease which ranges from simple steatosis (NAFL) to non-alcoholic steatohepatitis (NASH) and is characterized by lipid accumulation, inflammation activation, fibrosis, and cell death. To date, a number of preclinical studies or clinical trials associated with therapies targeting fatty acid metabolism, inflammatory factors and liver fibrosis are performed to develop effective drugs for NAFLD/NASH. However, few therapies are cell death signaling-targeted even though the various cell death modes are present throughout the progression of NAFLD/NASH. Here we summarize the four types of cell death including apoptosis, necroptosis, pyroptosis, and ferroptosis in the NAFLD and the underlying molecular mechanisms by which the pathogenic factors such as free fatty acid and LPS induce cell death in the pathogenesis of NAFLD. In addition, we also review the effects of cell death-targeted therapies on NAFLD. In summary, our review provides comprehensive insight into the roles of various cell death modes in the progression of NAFLD, which we hope will open new avenues for therapeutic intervention.
(© 2024. The Author(s).)
Databáze: MEDLINE
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