Effect of body position during weaning from total liquid ventilation in piglets.

Autor: Panaitescu A; Department of Pharmacology-Physiology, Faculty of Medicine and Health Sciences, Université de Sherbrooke, 3001 12e Avenue N, Sherbrooke, Québec J1H 5N4, Canada., Morin C; Department of Pharmacology-Physiology, Faculty of Medicine and Health Sciences, Université de Sherbrooke, 3001 12e Avenue N, Sherbrooke, Québec J1H 5N4, Canada., Boudaouara MA; Department of Mechanical Engineering, Faculty of Engineering, Université de Sherbrooke, 2500 Bd de l'Université, Sherbrooke, Québec J1K 2R1, Canada., Taillandier-Pensarini SG; Department of Pharmacology-Physiology, Faculty of Medicine and Health Sciences, Université de Sherbrooke, 3001 12e Avenue N, Sherbrooke, Québec J1H 5N4, Canada., Samson N; Department of Pharmacology-Physiology, Faculty of Medicine and Health Sciences, Université de Sherbrooke, 3001 12e Avenue N, Sherbrooke, Québec J1H 5N4, Canada., Praud JP; Department of Pharmacology-Physiology, Faculty of Medicine and Health Sciences, Université de Sherbrooke, 3001 12e Avenue N, Sherbrooke, Québec J1H 5N4, Canada., Micheau P; Department of Mechanical Engineering, Faculty of Engineering, Université de Sherbrooke, 2500 Bd de l'Université, Sherbrooke, Québec J1K 2R1, Canada., Fortin-Pellerin E; Department of Pharmacology-Physiology, Faculty of Medicine and Health Sciences, Université de Sherbrooke, 3001 12e Avenue N, Sherbrooke, Québec J1H 5N4, Canada. Electronic address: etienne.fortin-pellerin@usherbrooke.ca.
Jazyk: angličtina
Zdroj: Respiratory physiology & neurobiology [Respir Physiol Neurobiol] 2025 Jan; Vol. 331, pp. 104338. Date of Electronic Publication: 2024 Sep 06.
DOI: 10.1016/j.resp.2024.104338
Abstrakt: Objective: To determine if change in body position improves oxygen requirements and respiratory mechanics during the transition from total liquid ventilation (TLV) to gas ventilation.
Methods: Fourteen piglets underwent TLV, followed by a 2-hour weaning period under conventional gas ventilation. Subjects were randomized to the experimental group (Rotating - R), that was in prone position between the 10th and 30th minute of weaning, or to the static control group (Supine - S).
Results: Oxygenation index was lower in the R group at 30 minutes in prone position than that in the S group (1.9 [1.6; 2.8] vs 3.5 [3.1; 5.1], p = 0.001). This difference disappeared when subjects resumed the supine position (4.2 [3.8; 4.7] and 4.7 [3.8; 5.4], p = 0.4, for the R and S groups, respectively). The change in body position did not affect respiratory system compliance or inspiratory capacity.
Conclusion: Prone position improved oxygenation during weaning from TLV. The effect disappeared once piglets returned to the supine position.
Competing Interests: Declaration of Competing Interest P.M. declares to be a co-inventor of patents on liquid ventilation (US patents #7726,311 B2; US patent 2016/0271,348 A1; US patent 2021/0077,759 A1; European patent 21305533.8). P.M. is a shareholder of a start-up company dedicated to the commercialization of a liquid ventilator for ultra-fast hypothermia induction after cardiac arrest (Orixha). The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that can be construed as a potential conflict of interest.
(Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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