Association between FTO polymorphism and COVID-19 mortality among older adults: A population-based cohort study.
| Autor: | Hubacek JA; Institute of Clinical and Experimental Medicine, Experimental Medicine Centre, Prague, Czech Republic; Charles University, Third Department of Internal Medicine, First Faculty of Medicine, Prague, Czech Republic. Electronic address: jahb@ikem.cz., Capkova N; National Institute of Public Health, Prague, Czech Republic., Bobak M; University College London, Institute of Epidemiology and Health Care, London, United Kingdom; Masaryk University, RECETOX, Faculty of Science, Brno, Czech Republic., Pikhart H; University College London, Institute of Epidemiology and Health Care, London, United Kingdom; Masaryk University, RECETOX, Faculty of Science, Brno, Czech Republic. |
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| Jazyk: | angličtina |
| Zdroj: | International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases [Int J Infect Dis] 2024 Nov; Vol. 148, pp. 107232. Date of Electronic Publication: 2024 Sep 06. |
| DOI: | 10.1016/j.ijid.2024.107232 |
| Abstrakt: | Objectives: COVID-19 caused a global pandemic with millions of deaths. Fat mass and obesity-associated gene (FTO) (alias m 6 A RNA demethylase) and its functional rs17817449 polymorphism are candidates to influence COVID-19-associated mortality since methylation status of viral nucleic acids is an important factor influencing viral viability. Methods: We tested a population-based cohort of 5233 subjects (aged 63-87 years in 2020) where 70 persons died from COVID-19 and 394 from other causes during the pandemic period. Results: The frequency of GG homozygotes was higher among those who died from COVID-19 (34%) than among survivors (19%) or deaths from other causes (20%), P <0.005. After multiple adjustments, GG homozygotes had a higher risk of death from COVID-19 with odds ratio = 2.01 (95% confidence interval; 1.19-3.41, P <0.01) compared with carriers of at least one T allele. The FTO polymorphism was not associated with mortality from other causes. Conclusions: Our results suggest that FTO variability is a significant predictor of COVID-19-associated mortality in Caucasians. Competing Interests: Declarations of competing interest The authors have no competing interests to declare. (Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.) |
| Databáze: | MEDLINE |
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