Epidermal secretion-purified biosensing patch with hydrogel sebum filtering membrane and unidirectional flow microfluidic channels.

Autor: Wang Y; School of Microelectronics, Southern University of Science and Technology, Shenzhen, 518055, China., Zhang Z; School of Microelectronics, Southern University of Science and Technology, Shenzhen, 518055, China., Shi Y; School of Microelectronics, Southern University of Science and Technology, Shenzhen, 518055, China., Yu X; School of Microelectronics, Southern University of Science and Technology, Shenzhen, 518055, China., Zhang X; School of Microelectronics, Southern University of Science and Technology, Shenzhen, 518055, China., Ma X; School of Microelectronics, Southern University of Science and Technology, Shenzhen, 518055, China., Su J; School of Microelectronics, Southern University of Science and Technology, Shenzhen, 518055, China., Ding R; School of Microelectronics, Southern University of Science and Technology, Shenzhen, 518055, China., Lin Y; School of Microelectronics, Southern University of Science and Technology, Shenzhen, 518055, China. Electronic address: linyj2020@sustech.edu.cn.
Jazyk: angličtina
Zdroj: Biomaterials [Biomaterials] 2025 Feb; Vol. 313, pp. 122810. Date of Electronic Publication: 2024 Sep 03.
DOI: 10.1016/j.biomaterials.2024.122810
Abstrakt: The development of biosensing electronics for real-time sweat analysis has attracted increasing research interest due to their promising applications for non-invasive health monitoring. However, one of the critical challenges lies in the sebum interference that largely limits the sensing reliability in practical scenarios. Herein, we report a flexible epidermal secretion-purified biosensing patch with a hydrogel filtering membrane that can effectively eliminate the impact of sebum and sebum-soluble substances. The as-prepared sebum filtering membranes feature a dual-layer sebum-resistant structure based on the poly(hydroxyethyl methacrylate) hydrogel functionalized with nano-brush structured poly(sulfobetaine) to eliminate interferences and provide self-cleaning capability. Furthermore, the unidirectional flow microfluidic channels design based on the Tesla valve was incorporated into the biosensing patch to prevent external sebum contamination and allow effective sweat refreshing for reliable sensing. By seamlessly combining these components, the epidermal secretion-purified biosensing patch enables continuous monitoring of sweat uric acid, pH, and sodium ions with significantly improved accuracy of up to 12 %. The proposed strategy for enhanced sweat sensing reliability without sebum interference shows desirable compatibility for different types of biosensors and would inspire the advances of flexible and wearable devices for non-invasive healthcare.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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