Impact of Serum Phosphorus on Hemoglobin: A Literature Review.

Autor:	Zirino F; Unit of Nephrology and Dialysis, P.O. Maggiore 'Nino Baglieri', University of Messina, Messina, Italy., Lipari A; Unit of Nephrology and Dialysis, P.O. Maggiore 'Nino Baglieri', University of Messina, Messina, Italy., Tigano A; Unit of Nephrology and Dialysis, P.O. Maggiore 'Nino Baglieri', University of Messina, Messina, Italy., Giuffrida AE; Unit of Nephrology and Dialysis, P.O. Maggiore 'Nino Baglieri', University of Messina, Messina, Italy., Sessa C; Unit of Nephrology and Dialysis, P.O. Maggiore 'Nino Baglieri', University of Messina, Messina, Italy., Galeano D; Unit of Nephrology and Dialysis, P.O. Maggiore 'Nino Baglieri', University of Messina, Messina, Italy., Alessandrello I; Unit of Nephrology and Dialysis, P.O. Maggiore 'Nino Baglieri', University of Messina, Messina, Italy., Messina RM; Unit of Nephrology and Dialysis, P.O. Maggiore 'Nino Baglieri', University of Messina, Messina, Italy., Pilato R; Department of General Surgery and Medical-Surgical Specialty, University of Catania, Catania, Italy., Morale W; Unit of Nephrology and Dialysis, P.O. Maggiore 'Nino Baglieri', University of Messina, Messina, Italy., Calabrese V; Unit of Nephrology and Dialysis, Department of Clinical and Experimental Medicine, A.O.U. 'G. Martino', University of Messina, Messina, Italy.
Jazyk:	angličtina
Zdroj:	Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia [G Ital Nefrol] 2024 Aug 26; Vol. 41 (4). Date of Electronic Publication: 2024 Aug 26.
DOI:	10.69097/41-04-2024-03
Abstrakt:	Phosphorus is a macroelement found in the body, mostly in the bones as crystals of hydroxyapatite. Higher levels are found in patients affected by chronic kidney disease (CKD). Since the early stage of CKD phosphorous excretion is impaired, but the increase of PTH and FGF23 maintains its level in the normal range. In the last decades, the role of FGF23 in erythropoiesis was studied, and now it is well known for its role in anemia genesis in patients affected by conservative CKD. Both Hyperphosphatemia and anemia are two manifestations of CKD, but many studies showed a direct association between serum phosphorous and anemia. Phosphorus can be considered as the common point of more pathogenetic ways, independent of renal function: the overproduction of FGF23, the worsening of vascular disease, and the toxic impairment of erythropoiesis, including the induction of hemolysis. (Copyright by Società Italiana di Nefrologia SIN, Rome,Italy.)
Databáze:	MEDLINE
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