Radiological features in pediatric myelin oligodendrocyte glycoprotein antibody-associated disease-diagnostic criteria and lesion dynamics.

Autor: Pratt LT; Pediatric Radiology, Imaging Division, Tel Aviv Sourasky Medical Center, 6 Weizmann Street, 6423906, Tel Aviv, Israel. litalp@tlvmc.gov.il.; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. litalp@tlvmc.gov.il., Meirson H; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.; Pediatric Neurology Institute, Dana-Dwek Children's Hospital, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel., Shapira Rootman M; The Department of Diagnosing Imaging, Rambam Medical Center, Haifa, Israel., Ben-Sira L; Pediatric Radiology, Imaging Division, Tel Aviv Sourasky Medical Center, 6 Weizmann Street, 6423906, Tel Aviv, Israel.; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel., Shiran SI; Pediatric Radiology, Imaging Division, Tel Aviv Sourasky Medical Center, 6 Weizmann Street, 6423906, Tel Aviv, Israel.; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Jazyk: angličtina
Zdroj: Pediatric radiology [Pediatr Radiol] 2024 Sep 07. Date of Electronic Publication: 2024 Sep 07.
DOI: 10.1007/s00247-024-06023-2
Abstrakt: The spectrum of acquired pediatric demyelinating syndromes has been expanding over the past few years, to include myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD), as a distinct neuroimmune entity, in addition to pediatric-onset multiple sclerosis (POMS) and aquaporin 4-IgG-seropositive neuromyelitis optica spectrum disorder (AQP4+NMOSD). The 2023 MOGAD diagnostic criteria require supporting clinical or magnetic resonance imaging (MRI) features in patients with low positive myelin oligodendrocyte glycoprotein IgG titers or when the titers are not available, highlighting the diagnostic role of imaging in MOGAD. In this review, we summarize the key diagnostic features in MOGAD, in comparison to POMS and AQP4+NMOSD. We describe the lesion dynamics both during attack and over time. Finally, we propose a guideline on timing of imaging in clinical practice.
(© 2024. The Author(s).)
Databáze: MEDLINE
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