Neurological Implications of Poxvirus Infections: Pathogenesis, Neurotropism, and Clinical Manifestations.

Autor: Alissa M; Department of Medical Laboratory, College of Applied Medical Sciences, Prince Sattam bin Abdulaziz University, Al-Kharj, Saudi Arabia., Alzahrani KJ; Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Taif University, Taif, Saudi Arabia., Alsuwat MA; Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Taif University, Taif, Saudi Arabia.
Jazyk: angličtina
Zdroj: Reviews in medical virology [Rev Med Virol] 2024 Sep; Vol. 34 (5), pp. e2581.
DOI: 10.1002/rmv.2581
Abstrakt: Poxviridae is a diverse family of double-stranded DNA viruses, historically significant for diseases like smallpox caused by variola virus (VARV). These viruses exhibit unique cytoplasmic replication strategies, large genomes encoding numerous proteins, and the ability to cause severe cutaneous and systemic diseases. Recent attention has focused on their neurotropic potential, including mechanisms of CNS invasion, immune-mediated damage, and clinical manifestations such as encephalitis and myelitis. This review synthesises current knowledge on poxvirus neurotropism, highlighting pathophysiological mechanisms and clinical implications.
(© 2024 John Wiley & Sons Ltd.)
Databáze: MEDLINE
Externí odkaz: