Solvent-Controlled Divergent Cyclization of 3-Ylideneoxindoles with Ethyl 2-Diazoacetate: Access to Spirocyclopropyl and Spiropyrazolines Oxindoles.
| Autor: | Xie DX; School of Chemistry and Chemical Engineering, Guangzhou University, 230 Wai Huan Xi Road, Guangzhou, 510006, China., Huang YM; School of Chemistry and Chemical Engineering, Guangzhou University, 230 Wai Huan Xi Road, Guangzhou, 510006, China., Lin XM; School of Chemistry and Chemical Engineering, Guangzhou University, 230 Wai Huan Xi Road, Guangzhou, 510006, China., Kang ZH; Zhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica Chinese Academy of Sciences, Zhongshan, 528400, China., Ni CC; School of Chemistry and Chemical Engineering, Guangzhou University, 230 Wai Huan Xi Road, Guangzhou, 510006, China., Fu YT; School of Chemistry and Chemical Engineering, Guangzhou University, 230 Wai Huan Xi Road, Guangzhou, 510006, China., Ren Z; College of Pharmacy, Shenzhen Technology University, 3002 Lantian Road, Shenzhen, 518118, China., Liu YL; School of Chemistry and Chemical Engineering, Guangzhou University, 230 Wai Huan Xi Road, Guangzhou, 510006, China.; Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering, East China Normal University, 3663 North Zhongshan Rd., Shanghai, 200062, China. |
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| Jazyk: | angličtina |
| Zdroj: | Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2024 Dec 10; Vol. 30 (69), pp. e202402654. Date of Electronic Publication: 2024 Oct 29. |
| DOI: | 10.1002/chem.202402654 |
| Abstrakt: | Herein a catalyst-free solvent-controlled method for the divergent synthesis of spirocyclopropyl and spiropyrazoline oxindoles from 3-ylideneoxindoles and ethyl diazoacetate was developed. With ClCH (© 2024 Wiley-VCH GmbH.) |
| Databáze: | MEDLINE |
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