Daily Dynamics of Resting-State Electroencephalographic Theta and Gamma Fluctuations Are Associated With Cognitive Performance in Healthy Aging.

Autor:	Bennis K; Université de Caen Normandie, Inserm, EPHE-PSL, CHU de Caen, GIP Cyceron, U1077, NIMH, 14000 Caen, France., Eustache F; Université de Caen Normandie, Inserm, EPHE-PSL, CHU de Caen, GIP Cyceron, U1077, NIMH, 14000 Caen, France., Collette F; GIGA-CRC-In Vivo Imaging, Université de Liège and Belgian National Fund for Scientific Research, Liège, Belgium., Vandewalle G; GIGA-CRC-In Vivo Imaging, Université de Liège and Belgian National Fund for Scientific Research, Liège, Belgium., Hinault T; Université de Caen Normandie, Inserm, EPHE-PSL, CHU de Caen, GIP Cyceron, U1077, NIMH, 14000 Caen, France.
Jazyk:	angličtina
Zdroj:	The journals of gerontology. Series B, Psychological sciences and social sciences [J Gerontol B Psychol Sci Soc Sci] 2024 Nov 01; Vol. 79 (11).
DOI:	10.1093/geronb/gbae152
Abstrakt:	Objectives: Healthy age-related cognitive changes are highly heterogeneous across individuals. This variability is increasingly explained through the lens of spontaneous fluctuations of brain activity, now considered a powerful index of age-related changes. However, brain activity is a biological process modulated by circadian rhythms, and how these fluctuations evolve throughout the day is under investigation. Methods: We analyzed data from 101 healthy late middle-aged participants from the Cognitive Fitness in Aging study (68 women and 33 men; aged 50-69 years). Participants completed 5 electroencephalographic (EEG) recordings of spontaneous resting-state activity on the same day. We used weighted phase-lag index (wPLI) analyses as an index of the functional synchrony between brain regions couplings, and we computed daily global PLI fluctuation rates of the 5 recordings to assess the association with cognitive performance and β-amyloid and tau/neuroinflammation pathological markers. Results: We found that theta and gamma daily fluctuations in the salience-control executive internetwork (SN-CEN) are associated with distinct mechanisms underlying cognitive heterogeneity in aging. Higher levels of SN-CEN theta daily fluctuations appear to be deleterious for memory performance and were associated with higher tau/neuroinflammation rates. In contrast, higher levels of gamma daily fluctuations are positively associated with executive performance and were associated with lower rate of β-amyloid deposition. Discussion: Thus, accounting for daily EEG fluctuations of brain activity contributes to a better understanding of subtle brain changes underlying individuals' cognitive performance in healthy aging. Results also provide arguments for considering the time of day when assessing cognition for old adults in a clinical context. (© The Author(s) 2024. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.)
Databáze:	MEDLINE
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