Potential Predictor of Epigenetic Age Acceleration in Men: 2D:4D Finger Pattern.

Autor: Pruszkowska-Przybylska P; Department of Anthropology, Faculty of Biology and Environmental Protection, University of Łódź, Łódź, Poland., Noroozi R; Doctoral School of Exact and Natural Sciences, Jagiellonian University, Krakow, Poland.; Małopolska Centre of Biotechnology, Jagiellonian University, Kraków, Poland., Rudnicka J; Doctoral School of Exact and Natural Sciences, Jagiellonian University, Krakow, Poland.; Małopolska Centre of Biotechnology, Jagiellonian University, Kraków, Poland., Pisarek A; Laboratory of Anthropology, Institute of Zoology and Biomedical Research, Kraków, Poland., Wronka I; Laboratory of Anthropology, Institute of Zoology and Biomedical Research, Kraków, Poland., Kobus M; Institute of Biological Sciences, Faculty of Biology and Environmental Sciences, Cardinal Stefan Wyszynski University in Warsaw, Warsaw, Poland., Wysocka B; Central Forensic Laboratory of the Police, Warsaw, Poland., Ossowski A; Department of Forensic Genetics, Pomeranian Medical University in Szczecin, Szczecin, Poland., Spólnicka M; Center for Forensic Science University of Warsaw, Warsaw, Poland., Wiktorska J; MelissaMed M. Gauer, General Partnership, Łódź, Poland., Iljin A; Department of Plastic, Reconstructive and Aesthetic Surgery, Medical University of Lodz 90-153, Lodz, Poland., Pośpiech E; Department of Forensic Genetics, Pomeranian Medical University in Szczecin, Szczecin, Poland., Branicki W; Laboratory of Anthropology, Institute of Zoology and Biomedical Research, Kraków, Poland., Sitek A; Department of Anthropology, Faculty of Biology and Environmental Protection, University of Łódź, Łódź, Poland.
Jazyk: angličtina
Zdroj: American journal of human biology : the official journal of the Human Biology Council [Am J Hum Biol] 2024 Nov; Vol. 36 (11), pp. e24151. Date of Electronic Publication: 2024 Sep 06.
DOI: 10.1002/ajhb.24151
Abstrakt: Objectives: Second to fourth digit ratio is widely known indicator of prenatal sex hormones proportion. Higher prenatal androgenization results in longer fourth finger and lower 2D:4D index. The aim of this study was to determine whether the 2D:4D digit ratio is associated with DNA methylation (DNAm) age dependently on sex.
Material and Methods: The study included 182 adults (106 females and 76 males) with a mean age of 51.5 ± 13 years. The investigation consisted of three main parts: a survey, anthropometric dimensions measurements (fingers length) and methylome analysis using collected blood samples. Genome-wide methylation was analyzed using EPIC microarray technology. Epigenetic age and epigenetic age acceleration were calculated using several widely applied algorithms.
Results: Males with the female left hand pattern had more accelerated epigenetic age than those with the male pattern as calculated with PhenoAge and DNAmTL clocks.
Conclusions: Finger female pattern 2D:4D above or equal to 1 in males is associated with epigenetic age acceleration, indicating that prenatal exposure to estrogens in males may be related to aging process in the later ontogenesis.
(© 2024 Wiley Periodicals LLC.)
Databáze: MEDLINE
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