Metabolic Adaptation in Heart Failure and the Role of Ketone Bodies as Biomarkers.

Autor: Foster MW; Department of Medicine, Division of Cardiology, Thomas Jefferson University Hospital, 833 Chestnut Street, Suite 600, Philadelphia, PA, 19107, USA., Riley JM; Department of Medicine, Division of Cardiology, Thomas Jefferson University Hospital, 833 Chestnut Street, Suite 600, Philadelphia, PA, 19107, USA., Kaki PC; Sidney Kimmel Medical College, Thomas Jefferson University Hospital, Philadelphia, PA, USA., Al Soueidy A; Department of Medicine, Copper University Hospital, Camden, NJ, USA., Aligholiazadeh E; Department of Medicine, Copper University Hospital, Camden, NJ, USA., Rame JE; Department of Medicine, Division of Cardiology, Thomas Jefferson University Hospital, 833 Chestnut Street, Suite 600, Philadelphia, PA, 19107, USA. Eduardo.rame@jefferson.edu.
Jazyk: angličtina
Zdroj: Current heart failure reports [Curr Heart Fail Rep] 2024 Oct; Vol. 21 (5), pp. 498-503. Date of Electronic Publication: 2024 Sep 07.
DOI: 10.1007/s11897-024-00678-6
Abstrakt: Purpose of Review: The development and progression of heart failure is characterized by metabolic and physiologic adaptations allowing patients to cope with cardiac insufficiency. This review explores the changes in metabolism in heart failure and the potential role of biomarkers, particularly ketone bodies, in staging and prognosticating heart failure progression.
Recent Findings: Recent insights into myocardial metabolism shed light on the heart's response to stress, highlighting the shift towards reliance on ketone bodies as an alternative fuel source. Elevated blood ketone levels have been shown to correlate with the severity of cardiac dysfunction, emphasizing their potential as prognostic indicators. Furthermore, studies exploring therapeutic interventions targeting specific metabolic pathways offer promise for improving outcomes in heart failure. Ketones have prognostic utility in heart failure, and potentially, an avenue for therapeutic intervention. Challenges remain in deciphering the optimal balance between metabolic support and exacerbating cardiac remodeling. Future research endeavors must address these complexities to advance personalized approaches in managing heart failure.
(© 2024. The Author(s).)
Databáze: MEDLINE
Externí odkaz: