Electrochemical sensor based on Cu 2-x S/graphene heterostructures for sub-picomolar dopamine detection.

Autor: Ai D; State Key Laboratory of Electrical Insulation and Power Equipment, School of Electrical Engineering, Xi'an Jiaotong University, Xi'an, 710049, Shaanxi, China. aiding@xjtu.edu.cn.; National Health Commission Key Laboratory of Forensic Sciences (NKLF) and National Biosafety Evidence Foundation (NBEF), Bio-Evidence Sciences Academy, Xi'an Jiaotong University, Xi'an, 710049, Shaanxi, China. aiding@xjtu.edu.cn., Yu H; State Key Laboratory of Electrical Insulation and Power Equipment, School of Electrical Engineering, Xi'an Jiaotong University, Xi'an, 710049, Shaanxi, China., Han Y; State Key Laboratory of Electrical Insulation and Power Equipment, School of Electrical Engineering, Xi'an Jiaotong University, Xi'an, 710049, Shaanxi, China., Chang Y; State Key Laboratory of Electrical Insulation and Power Equipment, School of Electrical Engineering, Xi'an Jiaotong University, Xi'an, 710049, Shaanxi, China., Ma Y; State Key Laboratory of Electrical Insulation and Power Equipment, School of Electrical Engineering, Xi'an Jiaotong University, Xi'an, 710049, Shaanxi, China., Wu C; State Key Laboratory of Electrical Insulation and Power Equipment, School of Electrical Engineering, Xi'an Jiaotong University, Xi'an, 710049, Shaanxi, China., Liu M; National Health Commission Key Laboratory of Forensic Sciences (NKLF) and National Biosafety Evidence Foundation (NBEF), Bio-Evidence Sciences Academy, Xi'an Jiaotong University, Xi'an, 710049, Shaanxi, China., Zhu Y; National Health Commission Key Laboratory of Forensic Sciences (NKLF) and National Biosafety Evidence Foundation (NBEF), Bio-Evidence Sciences Academy, Xi'an Jiaotong University, Xi'an, 710049, Shaanxi, China., Li S; National Health Commission Key Laboratory of Forensic Sciences (NKLF) and National Biosafety Evidence Foundation (NBEF), Bio-Evidence Sciences Academy, Xi'an Jiaotong University, Xi'an, 710049, Shaanxi, China., Dong C; Materials Research Institute, The Pennsylvania State University, University Park, PA, 16802, USA. cqd5506@psu.edu., Cheng Y; State Key Laboratory of Electrical Insulation and Power Equipment, School of Electrical Engineering, Xi'an Jiaotong University, Xi'an, 710049, Shaanxi, China.; National Health Commission Key Laboratory of Forensic Sciences (NKLF) and National Biosafety Evidence Foundation (NBEF), Bio-Evidence Sciences Academy, Xi'an Jiaotong University, Xi'an, 710049, Shaanxi, China.
Jazyk: angličtina
Zdroj: Mikrochimica acta [Mikrochim Acta] 2024 Sep 07; Vol. 191 (10), pp. 578. Date of Electronic Publication: 2024 Sep 07.
DOI: 10.1007/s00604-024-06651-3
Abstrakt: Detecting dopamine (DA) in biological samples is vital to understand its crucial role in numerous physiological processes, such as motion, cognition, and reward stimulus. In this work, p-type graphene on sapphire, synthesized via chemical vapor deposition, serves as substrate for the preparation of p-type Cu 2-x S films through solid-phase sulfurization. The optimized Cu 2-x S/graphene heterostructure, prepared at 250 °C using a 15-nm copper film sulfurized for 2 h, exhibits superior electron transfer performance, ideal for electrochemical sensing. It is confirmed that the spontaneous charge transfer from graphene to Cu 2-x S, higher Cu(II)/Cu(I) ratio (~ 0.8), and the presence of well-defined nanocrystalline structures with an average size of ~ 35 nm in Cu 2-x S significantly contribute to the improved electron transfer of the heterostructure. The electrochemical sensor based on Cu 2-x S/graphene heterostructure demonstrates remarkable sensitivity towards DA, with a detection limit as low as 100 fM and a dynamic range greater than 10 9 from 100 fM to 100 μM. Additionally, it exhibits excellent selectivity even in the presence of uric acid and ascorbic acid 100 times higher, alongside notable storage and measurement stability and repeatability. Impressively, the sensor also proves capable of detecting DA concentrations as low as 100 pM in rat serum, showcasing its potential for clinically relevant analytes and promising applications in sensitive, selective, reliable, and efficient point-of-care diagnostics.
(© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, part of Springer Nature.)
Databáze: MEDLINE
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