Prospective single-arm trial on feasibility and safety of an endoscopic robotic system for colonic endoscopic submucosal dissection.

Autor:	Chiu PWY; Surgery, The Chinese University of Hong Kong, Hong Kong, Hong Kong.; Institute of Digestive Disease and State Key Laboratory of GI Diseases, The Chinese University of Hong Kong, Hong Kong, Hong Kong.; Multi-scale Medical Robotics Center, InnoHK, Hong Kong, Hong Kong., Yip HC; Surgery, The Chinese University of Hong Kong, Hong Kong, Hong Kong.; Institute of Digestive Disease and State Key Laboratory of GI Diseases, The Chinese University of Hong Kong, Hong Kong, Hong Kong.; Multi-scale Medical Robotics Center, InnoHK, Hong Kong, Hong Kong., Chu S; Surgery, The Chinese University of Hong Kong, Hong Kong, Hong Kong., Chan SM; Surgery, The Chinese University of Hong Kong, Hong Kong, Hong Kong.; Institute of Digestive Disease and State Key Laboratory of GI Diseases, The Chinese University of Hong Kong, Hong Kong, Hong Kong.; Multi-scale Medical Robotics Center, InnoHK, Hong Kong, Hong Kong., Lau HSL; Institute of Digestive Disease and State Key Laboratory of GI Diseases, The Chinese University of Hong Kong, Hong Kong, Hong Kong., Tang RSY; Institute of Digestive Disease and State Key Laboratory of GI Diseases, The Chinese University of Hong Kong, Hong Kong, Hong Kong., Phee SJ; School of Mechanical and Aerospace Engineering, Nanyang Technological University, Singapore, Singapore., Ho KY; Gastroenterology and Hepatology, National University of Singapore Yong Loo Lin School of Medicine, Singapore, Singapore., Ng SSM; Surgery, The Chinese University of Hong Kong, Hong Kong, Hong Kong.
Jazyk:	angličtina
Zdroj:	Endoscopy [Endoscopy] 2024 Nov 06. Date of Electronic Publication: 2024 Nov 06.
DOI:	10.1055/a-2411-0892
Abstrakt:	Background: The development of the EndoMaster "Endoluminal Access Surgical Efficacy" (EASE) system aims to enhance the safety and efficacy of colonic endoscopic submucosal dissection (ESD) through two flexible robotic arms. This is the first clinical trial to evaluate the performance of colorectal ESD using EndoMaster. Method: Patients with early mucosal colorectal neoplasia that was not suitable for en bloc resection with snare-based techniques were recruited. The EndoMaster EASE robotic system consisted of an independently designed flexible robotic platform with two robotic arms. The primary outcome was the complete resection rate using EndoMaster. Secondary outcomes included operating time, hospital stay, procedure-related complications, and oncologic outcomes. Results: 43 patients underwent robotic ESD, with a median robotic dissection time of 49 minutes. The technical success rate was 86.0%, while en bloc resection rate among cases with technical success was 94.6%. The complete resection rate was 83.8% and the median size of specimen was 35 mm (range 15-90 mm). The median hospital stay was 2 (range 1-7) days and there was one delayed bleed after 4 days, which was controlled endoscopically. One patient sustained perforation during the procedure, which was completely closed using clips without sequelae. Two patients were treated by salvage surgery. Conclusion: This first clinical trial confirmed the safety and efficacy of performing colorectal ESD using the EndoMaster EASE robotic system. Competing Interests: P.W.Y. Chiu has served as a scientific advisor for EndoMaster Pte Ltd. S.J. Phee and K.Y. Ho are founders of EndoMaster Pte Ltd, Singapore. H.C. Yip, S. Chu, S.M. Chan, L.H.S. Lau, R.S.Y. Tang, and S.S.M. Ng declare that they have no conflict of interest. (The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).)
Databáze:	MEDLINE
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