Chitosan nanoparticles encapsulated Piper betle essential oil alleviates Alzheimer's disease associated pathology in Caenorhabditis elegans.

Autor: Muthusamy V; Department of Nanoscience and Technology, Bharathiar University, Coimbatore - 641046, Tamil Nadu, India., Govindhan T; Department of Zoology, Bharathiar University, Coimbatore - 641046, Tamil Nadu, India., Amirthalingam M; Department of Biology, Gus R. Douglass Institute, West Virginia State University, Institute, WV 25112, USA., Pottanthara Ashokan A; Department of Zoology, Bharathiar University, Coimbatore - 641046, Tamil Nadu, India., Thangavel H; Department of Nanoscience and Technology, Bharathiar University, Coimbatore - 641046, Tamil Nadu, India., Palanisamy S; Department of Zoology, Bharathiar University, Coimbatore - 641046, Tamil Nadu, India. Electronic address: sunpalan@gmail.com., Paramasivam P; Department of Nanoscience and Technology, Bharathiar University, Coimbatore - 641046, Tamil Nadu, India. Electronic address: premasudha@buc.edu.in.
Jazyk: angličtina
Zdroj: International journal of biological macromolecules [Int J Biol Macromol] 2024 Nov; Vol. 279 (Pt 3), pp. 135323. Date of Electronic Publication: 2024 Sep 04.
DOI: 10.1016/j.ijbiomac.2024.135323
Abstrakt: A multifaceted approach in treating Alzheimer's disease (AD), a neurodegenerative condition that poses health risks in the aging population is explored in this investigation via encapsulating Piper betle essential oil (PBEO) in chitosan nanoparticles (ChNPs) to improve solubility and efficacy of PBEO. PBEO-ChNPs mitigated AD-like features more effectively than free PBEO by delaying paralysis progression and reducing serotonin hypersensitivity, ROS levels, Aβ deposits, and neurotoxic Aβ-oligomers in the Caenorhabditis elegans AD model. PBEO-ChNPs significantly improved lifespan, neuronal health, healthspan, cognitive function, and reversed deficits in chemotaxis and reproduction. PBEO-ChNPs also induced stress response genes daf-16, sod-3, and hsp-16.2. The participation of the DAF-16 pathway in reducing Aβ-induced toxicity was confirmed by daf-16 RNAi treatment, and upregulation of autophagy genes leg-1, unc-51, and bec-1 was noted. This study is the first to demonstrate an alternative biopolymeric nanoformulation with natural PBEO and chitosan, in mitigating AD and its associated symptoms.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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