Off-the-shelf CAR-T cells could prove paradigm shifting for autoimmune diseases.
| Autor: | Baker DJ; Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Parker Institute for Cancer Immunotherapy, University of Pennsylvania, Philadelphia, PA 19104, USA; Cardiovascular Institute, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, PA 19104, USA. Electronic address: bakerda@pennmedicine.upenn.edu., June CH; Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Parker Institute for Cancer Immunotherapy, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: cjune@upenn.edu. |
|---|---|
| Jazyk: | angličtina |
| Zdroj: | Cell [Cell] 2024 Sep 05; Vol. 187 (18), pp. 4826-4828. |
| DOI: | 10.1016/j.cell.2024.07.056 |
| Abstrakt: | Early reports suggest that chimeric antigen receptor (CAR)-T therapy has remarkable potential for treating autoimmune disease. Current approaches rely on autologous CAR-T cells, creating a bottleneck to the broad deployment of this therapy. In this issue of Cell, Wang et al. 1 report the first use of allogeneic CAR-T cells in three patients with systemic autoimmune disease. Competing Interests: Declaration of interests C.H.J. is an inventor on patents and/or patent applications licensed to Novartis Institutes for BioMedical Research and receives license revenue from such licenses. C.H.J is a scientific cofounder of Tmunity Therapeutics, BlueWhale Bio, Dispatch Bio, and Capstan Therapeutics. C.H.J is a member of the scientific advisory boards of AC Immune, BlueSphere Bio, Cabaletta, Carisma, Cartography, Cellares, Celldex, Danaher, Decheng, Kite Gilead, Poseida, Verismo, Viracta, viTToria Bio, and WIRB-Copernicus. (Copyright © 2024 Elsevier Inc. All rights reserved.) |
| Databáze: | MEDLINE |
| Externí odkaz: |
|