Physiological properties of auditory neurons responding to omission deviants in the anesthetized rat.

Autor: Lao-Rodríguez AB; Cognitive and Auditory Neuroscience Laboratory (CANELAB), Institute of Neuroscience of Castilla y León, University of Salamanca, Spain; Department of Cell Biology and Pathology, University of Salamanca, Spain; Institute for Biomedical Research of Salamanca (IBSAL), Salamanca, Spain., Pérez-González D; Cognitive and Auditory Neuroscience Laboratory (CANELAB), Institute of Neuroscience of Castilla y León, University of Salamanca, Spain; Department of Basic Psychology, Psychobiology and Methodology of Behavioral Sciences, University of Salamanca, Spain; Institute for Biomedical Research of Salamanca (IBSAL), Salamanca, Spain., Malmierca MS; Cognitive and Auditory Neuroscience Laboratory (CANELAB), Institute of Neuroscience of Castilla y León, University of Salamanca, Spain; Department of Cell Biology and Pathology, University of Salamanca, Spain; Institute for Biomedical Research of Salamanca (IBSAL), Salamanca, Spain. Electronic address: msm@usal.es.
Jazyk: angličtina
Zdroj: Hearing research [Hear Res] 2024 Oct; Vol. 452, pp. 109107. Date of Electronic Publication: 2024 Aug 28.
DOI: 10.1016/j.heares.2024.109107
Abstrakt: The detection of novel, low probability events in the environment is critical for survival. To perform this vital task, our brain is continuously building and updating a model of the outside world; an extensively studied phenomenon commonly referred to as predictive coding. Predictive coding posits that the brain is continuously extracting regularities from the environment to generate predictions. These predictions are then used to supress neuronal responses to redundant information, filtering those inputs, which then automatically enhances the remaining, unexpected inputs. We have recently described the ability of auditory neurons to generate predictions about expected sensory inputs by detecting their absence in an oddball paradigm using omitted tones as deviants. Here, we studied the responses of individual neurons to omitted tones by presenting individual sequences of repetitive pure tones, using both random and periodic omissions, presented at both fast and slow rates in the inferior colliculus and auditory cortex neurons of anesthetized rats. Our goal was to determine whether feature-specific dependence of these predictions exists. Results showed that omitted tones could be detected at both high (8 Hz) and slow repetition rates (2 Hz), with detection being more robust at the non-lemniscal auditory pathway.
Competing Interests: Declaration of competing interest The authors declare that they have no competing interests.
(Copyright © 2024 The Author(s). Published by Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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