| Autor: |
Kim IH, Nam JH, Kim CK, Choi YJ, Lee H, An BM, Lee NJ, Jeong H, Lee SY, Yeo SG, Lee EK, Lee YJ, Rhee JE, Lee SW, Jee Y, Kim EJ |
| Jazyk: |
angličtina |
| Zdroj: |
Emerging infectious diseases [Emerg Infect Dis] 2024 Oct; Vol. 30 (10), pp. 2033-2041. Date of Electronic Publication: 2024 Sep 06. |
| DOI: |
10.3201/eid3010.240583 |
| Abstrakt: |
The prevalence of highly pathogenic avian influenza (HPAI) A(H5N1) viruses has increased in wild birds and poultry worldwide, and concomitant outbreaks in mammals have occurred. During 2023, outbreaks of HPAI H5N1 virus infections were reported in cats in South Korea. The H5N1 clade 2.3.4.4b viruses isolated from 2 cats harbored mutations in the polymerase basic protein 2 gene encoding single amino acid substitutions E627K or D701N, which are associated with virus adaptation in mammals. Hence, we analyzed the pathogenicity and transmission of the cat-derived H5N1 viruses in other mammals. Both isolates caused fatal infections in mice and ferrets. We observed contact infections between ferrets, confirming the viruses had high pathogenicity and transmission in mammals. Most HPAI H5N1 virus infections in humans have occurred through direct contact with poultry or a contaminated environment. Therefore, One Health surveillance of mammals, wild birds, and poultry is needed to prevent potential zoonotic threats. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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