Microbiome-Mucosal Immunity Nexus: Driving Forces in Respiratory Disease Progression.

Autor: Park YC; Department of Systems Biotechnology, Chung-Ang University, Anseong, 17546, Republic of Korea., Choi SY; Department of Systems Biotechnology, Chung-Ang University, Anseong, 17546, Republic of Korea., Cha Y; Department of Systems Biotechnology, Chung-Ang University, Anseong, 17546, Republic of Korea., Yoon HW; Department of Systems Biotechnology, Chung-Ang University, Anseong, 17546, Republic of Korea., Son YM; Department of Systems Biotechnology, Chung-Ang University, Anseong, 17546, Republic of Korea. Son0177@cau.ac.kr.
Jazyk: angličtina
Zdroj: Journal of microbiology (Seoul, Korea) [J Microbiol] 2024 Sep; Vol. 62 (9), pp. 709-725. Date of Electronic Publication: 2024 Sep 06.
DOI: 10.1007/s12275-024-00167-4
Abstrakt: The importance of the complex interplay between the microbiome and mucosal immunity, particularly within the respiratory tract, has gained significant attention due to its potential implications for the severity and progression of lung diseases. Therefore, this review summarizes the specific interactions through which the respiratory tract-specific microbiome influences mucosal immunity and ultimately impacts respiratory health. Furthermore, we discuss how the microbiome affects mucosal immunity, considering tissue-specific variations, and its capacity in respiratory diseases containing asthma, chronic obstructive pulmonary disease, and lung cancer. Additionally, we investigate the external factors which affect the relationship between respiratory microbiome and mucosal immune responses. By exploring these intricate interactions, this review provides valuable insights into the potential for microbiome-based interventions to modulate mucosal immunity and alleviate the severity of respiratory diseases.
(© 2024. The Author(s), under exclusive licence to Microbiological Society of Korea.)
Databáze: MEDLINE
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