Lautropia mirabilis sepsis in immunodeficiency: first report and genomic features.

Autor: Genseke S; Medical Faculty, Institute of Medical Microbiology and Hospital Hygiene, Otto von Guericke University Magdeburg, Magdeburg, Germany., Berisha M; Medical Faculty, Department of Hematology, Oncology and Cell Therapy, Otto von Guericke University Magdeburg, Magdeburg, Germany., Teerstegen A; Medical Faculty, Institute of Medical Microbiology and Hospital Hygiene, Otto von Guericke University Magdeburg, Magdeburg, Germany., Meyer B; Medical Faculty, Institute of Medical Microbiology and Hospital Hygiene, Otto von Guericke University Magdeburg, Magdeburg, Germany., Kaasch AJ; Medical Faculty, Institute of Medical Microbiology and Hospital Hygiene, Otto von Guericke University Magdeburg, Magdeburg, Germany.; Medical Faculty, Health Campus Immunology, Infectiology and Inflammation (GCI), Otto von Guericke University Magdeburg, Magdeburg, Germany., Färber J; Medical Faculty, Institute of Medical Microbiology and Hospital Hygiene, Otto von Guericke University Magdeburg, Magdeburg, Germany., Schalk E; Medical Faculty, Department of Hematology, Oncology and Cell Therapy, Otto von Guericke University Magdeburg, Magdeburg, Germany., Zautner AE; Medical Faculty, Institute of Medical Microbiology and Hospital Hygiene, Otto von Guericke University Magdeburg, Magdeburg, Germany. azautne@gwdg.de.; Center for Health and Medical Prevention (CHaMP), Otto von Guericke University, Magdeburg, Germany. azautne@gwdg.de., Esser T; Medical Faculty, Institute of Medical Microbiology and Hospital Hygiene, Otto von Guericke University Magdeburg, Magdeburg, Germany. torben.esser@med.ovgu.de., Kahlfuß S; Medical Faculty, Institute of Medical Microbiology and Hospital Hygiene, Otto von Guericke University Magdeburg, Magdeburg, Germany. sascha.kahlfuss@med.ovgu.de.; Medical Faculty, Institute of Molecular and Clinical Immunology, Otto von Guericke University Magdeburg, Magdeburg, Germany. sascha.kahlfuss@med.ovgu.de.; Medical Faculty, Health Campus Immunology, Infectiology and Inflammation (GCI), Otto von Guericke University Magdeburg, Magdeburg, Germany. sascha.kahlfuss@med.ovgu.de.; Center for Health and Medical Prevention (CHaMP), Otto von Guericke University, Magdeburg, Germany. sascha.kahlfuss@med.ovgu.de.
Jazyk: angličtina
Zdroj: Infection [Infection] 2024 Sep 06. Date of Electronic Publication: 2024 Sep 06.
DOI: 10.1007/s15010-024-02388-6
Abstrakt: Purpose: Lautropia mirabilis is a Gram-negative, facultative anaerobic coccus, which has been detected mainly in respiratory sites of immunodeficient patients suffering from HIV or cystic fibrosis. To date, knowledge about the pathogenicity of L. mirabilis is spare due to the small numbers of documented cases.
Methods: We present a literature review and report the case of a 39-year-old female diagnosed with common variable immunodeficiency (CVID) with IgG and IgA deficiency suffering from a sepsis with L. mirabilis. As no fully closed L. mirabilis genome besides the type strain was available to date, we additionally performed complete genome sequencing of L. mirabilis.
Results: The patient was admitted to our hospital with recurrent episodes of fever. Here, we detected L. mirabilis in two different blood cultures. The bacterium was tested susceptible to and treated with meropenem. As the origin of L. mirabilis sepsis, we observed an active periodontitis likely due to impaired IgA levels and mucosal insufficiency as a consequence of CVID. Whole genome sequencing of L. mirabilis revealed several genes important for host cell invasion and intracellular survival of the pathogen.
Conclusions: Our case highlights the importance of L. mirabilis in immunocompromised patients also in other compartments than the respiratory tract.
(© 2024. Springer-Verlag GmbH Germany, part of Springer Nature.)
Databáze: MEDLINE
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