Lipid metabolism reprogramming in renal cell carcinomas.

Autor: Abduljabbar MK; Biotechnology Department, College of Applied Science, Fallujah University, Fallujah, Iraq., Merza M; Clinical Analysis Department, Hawler Medical University, Kurdistan Regional Government, Erbil, Iraq. talarahmadmerza@gmail.com.; Medical Biochemical Analysis Department, College of Health Technology, Cihan University, Erbil, Kurdistan Region, Iraq. talarahmadmerza@gmail.com., Aziz A; Faculty of Pharmacy, Tishk International University, Kurdistan Region of Iraq, Erbil, Iraq. abdulgader.aziz@tiu.edu.ig., Menon SV; Department of Chemistry and Biochemistry, School of Sciences, JAIN (Deemed to Be University), Bangalore, Karnataka, India., Kaur M; Department of Sciences, Vivekananda Global University, Jaipur, Rajasthan, 303012, India., Aminov Z; Department of Public Health and Healthcare Management, Samarkand State Medical University, 18 Amir Temur Street, Samarkand, Uzbekistan., Rab SO; Department of Clinical Laboratory Sciences, College of Applied Medical Science, King Khalid University, Abha, Saudi Arabia., Hjazi A; Department of Medical Laboratory, College of Applied Medical Sciences, Prince Sattam Bin Abdulaziz University, 11942, Al-Kharj, Saudi Arabia., Mustafa YF; Department of Pharmaceutical Chemistry, College of Pharmacy, University of Mosul, Mosul-41001, Iraq., Gabel BC; Medical Laboratory Technique College, the Islamic University, Najaf, Iraq.; Medical Laboratory Technique College, the Islamic University of Al Diwaniyah, Al Diwaniyah, Iraq.; Medical Laboratory Technique College, the Islamic University of Babylon, Babylon, Iraq.
Jazyk: angličtina
Zdroj: Medical oncology (Northwood, London, England) [Med Oncol] 2024 Sep 06; Vol. 41 (10), pp. 243. Date of Electronic Publication: 2024 Sep 06.
DOI: 10.1007/s12032-024-02484-5
Abstrakt: This study investigates the intricate mechanisms underlying the correlation between elevated consumption of harmful fats and the onset of kidney malignancies. The rise in global obesity rates has been accompanied by an increased prevalence of renal cancers, prompting an exploration into the molecular pathways and biological processes linking these phenomena. Through an extensive review of current literature and clinical studies, we identify potential key factors contributing to the carcinogenic influence of harmful fats on renal tissues. Our analysis highlights the role of adipose tissue-derived factors, inflammatory mediators, and lipid metabolism dysregulation in fostering a microenvironment conducive to renal tumorigenesis. Furthermore, we delve into the impact of harmful fats on signaling pathways associated with cell proliferation, apoptosis evasion, and angiogenesis within the renal parenchyma. This review underscores the importance of elucidating the molecular intricacies linking lipid metabolism and kidney malignancies, offering a foundation for future research and the development of targeted preventive and therapeutic interventions. The findings discussed herein contribute to our understanding of the complex relationship between lipid mediators and renal cancer, providing a basis for public health strategies aimed at mitigating the impact of harmful fats on kidney health.
(© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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