Heritability and genetic correlations of obesity indices and cardiometabolic traits in the Northern Chinese families.

Autor: Lin B; Department of Epidemiology and Statistics, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and School of Basic Medicine, Peking Union Medical College, Beijing, China.; State Key Laboratory of Common Mechanism Research for Major Diseases, Beijing, China., Pan L; Department of Epidemiology and Statistics, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and School of Basic Medicine, Peking Union Medical College, Beijing, China.; State Key Laboratory of Common Mechanism Research for Major Diseases, Beijing, China., He H; Department of Epidemiology and Statistics, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and School of Basic Medicine, Peking Union Medical College, Beijing, China.; State Key Laboratory of Common Mechanism Research for Major Diseases, Beijing, China., Hu Y; Department of Epidemiology and Statistics, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and School of Basic Medicine, Peking Union Medical College, Beijing, China.; State Key Laboratory of Common Mechanism Research for Major Diseases, Beijing, China., Tu J; Department of Epidemiology and Statistics, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and School of Basic Medicine, Peking Union Medical College, Beijing, China.; State Key Laboratory of Common Mechanism Research for Major Diseases, Beijing, China., Zhang L; Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing, China., Cui Z; Department of Chronic and Noncommunicable Disease Prevention and Control, Hebei Provincial Center for Disease Control and Prevention, Shijiazhuang, Hebei, China., Ren X; Department of Chronic and Noncommunicable Disease Prevention and Control, Gansu Provincial Center for Disease Control and Prevention, Lanzhou, Gansu, China., Wang X; Institute of Biomedical Engineering, Chinese Academy of Medical Sciences, Tianjin, China., Nai J; Clinical Laboratory, Beijing Hepingli Hospital, Beijing, China., Shan G; Department of Epidemiology and Statistics, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and School of Basic Medicine, Peking Union Medical College, Beijing, China.; State Key Laboratory of Common Mechanism Research for Major Diseases, Beijing, China.; School of Population Medicine and Public Health, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Jazyk: angličtina
Zdroj: Annals of human genetics [Ann Hum Genet] 2025 Jan; Vol. 89 (1), pp. 1-11. Date of Electronic Publication: 2024 Sep 06.
DOI: 10.1111/ahg.12578
Abstrakt: Objective: This study aimed to investigate the heritability of various obesity indices and their shared genetic factors with cardiometabolic traits in the Chinese nuclear family.
Methods: A total of 1270 individuals from 538 nuclear families were included in this cross-sectional study. Different indices were used to quantify fat mass and distribution, including body index mass (BMI), visceral fat index (VFI), and body fat percent (BFP). Heritability and genetic correlations for all quantitative traits were estimated using variance component models. The susceptibility-threshold model was utilized to estimate the heritability for binary traits.
Results: Heritability estimates for obesity indices were highest for BMI (59%), followed by BFP (49%), and VFI (40%). Heritability estimates for continuous cardiometabolic traits varied from 24% to 50%. All obesity measures exhibited consistently significant positive genetic correlations with blood pressure, fasting blood glucose, and uric acid (r G range: 0.26-0.57). However, diverse genetic correlations between various obesity indices and lipid profiles were observed. Significant genetic correlations were limited to specific pairs: BFP and total cholesterol (r G  = 0.24), BFP and low-density lipoprotein cholesterol (r G  = 0.25), and VFI and triglyceride (r G  = 0.33).
Conclusion: The genetic overlap between various obesity indices and cardiometabolic traits underscores the importance of pleiotropic genes. Further studies are warranted to investigate specific shared genetic and environmental factors between obesity and cardiometabolic diseases.
(© 2024 University College London (UCL) and John Wiley & Sons Ltd.)
Databáze: MEDLINE
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