Reference Values of Ceruloplasmin across the Adult Age Range in a Large Italian Healthy Population.

Autor:	Pelucchi S; Department of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy., Risca G; Department of Medicine and Surgery, Bicocca Bioinformatics Biostatistics and Bioimaging B4 Center, University of Milan-Bicocca, Monza, Italy., Lanzafame C; Immunotransfusional Unit, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy., Scollo CM; Immunotransfusional Unit, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy., Garofalo A; Department of Laboratory Medicine, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy., Martinez D; Department of Laboratory Medicine, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy., Mariani R; SSD Rare Diseases-European Reference Network for Rare Hematological Diseases-EuroBloodNet-Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy., Botti M; SSD Rare Diseases-European Reference Network for Rare Hematological Diseases-EuroBloodNet-Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy., Capitoli G; Department of Medicine and Surgery, Bicocca Bioinformatics Biostatistics and Bioimaging B4 Center, University of Milan-Bicocca, Monza, Italy., Rossi F; Immunotransfusional Unit, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy., Casati M; Department of Laboratory Medicine, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy., Piperno A; Centro Ricerca Tettamanti, Monza, Italy., Galimberti S; Department of Medicine and Surgery, Bicocca Bioinformatics Biostatistics and Bioimaging B4 Center, University of Milan-Bicocca, Monza, Italy.; Biostatistics and Clinical Epidemiology, Fondazione IRCCS San Gerardo Dei Tintori, Monza, Italy.
Jazyk:	angličtina
Zdroj:	The journal of applied laboratory medicine [J Appl Lab Med] 2024 Nov 04; Vol. 9 (6), pp. 1053-1063.
DOI:	10.1093/jalm/jfae098
Abstrakt:	Background: Ceruloplasmin (Cp) is the most important serum copper transport protein playing a key role in the binding of iron to transferrin. It is a positive acute-phase response protein and the first-level diagnostic marker for Wilson disease and aceruloplasminemia. However, standardization of Cp measurement has not been successful, and assay specific reference levels of Cp are required. Methods: From May 2019 to July 2022, we enrolled 1706 consecutive healthy Italian blood donors (1285 men and 421 women, 18 to 65 years) to identify the reference intervals of serum Cp through quantile regression and evaluate the relationship of Cp with age, sex, iron, and metabolic status through linear regression. Results: We found that mean serum Cp was influenced by sex and slightly by age. The lower reference Cp value rose slightly with increasing age in both men and women. The upper reference value increased, reaching a plateau of about 25 mg/dL around 25 years in men, while in women it initially increased to around 45 mg/dL in young adults to fall sharply below 30 mg/dL for adults after their fifties. Conclusions: We showed that the normal reference curves of serum Cp vary according to sex in a large population of healthy adults. While the lower reference values did not appear to be influenced by age and sex, the upper ones differed according to sex and age showing a particularly high variability in women, possibly reflecting different hormonal status. (© Association for Diagnostics & Laboratory Medicine 2024. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.)
Databáze:	MEDLINE
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