The ankle-brachial index, gastrocnemius mitochondrial respirometry, and walking performance in people with and without peripheral artery disease.
| Autor: | McDermott MM; Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.; Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Dayanidhi S; Shirley Ryan AbilityLab, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Leeuwenburgh C; Department of Aging and Geriatric Research, University of Florida, Gainesville, FL, USA., Wohlgemuth SE; Department of Aging and Geriatric Research, University of Florida, Gainesville, FL, USA., Ferrucci L; Division of Intramural Research, National Institute on Aging, Baltimore, MD, USA., Peterson CA; Center for Muscle Biology, University of Kentucky, Lexington, KY, USA., Tian L; Department of Health Research and Policy, Stanford University, Stanford, CA, USA., Sufit R; Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Zhao L; Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Slysz J; Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.; Current: Department of Physiology and Biophysics, Dalhousie University, Nova Scotia, Canada., Polonsky TS; Department of Medicine, University of Chicago, Chicago, IL, USA., Guralnik JM; Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD, USA., Kibbe MR; Department of Surgery and Biomedical Engineering, University of Virginia School of Medicine, Charlottesville, VA, USA., Ho KJ; Department of Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Criqui MH; Department of Preventive Medicine, Family Medicine and Public Health, University of San Diego California, San Diego, CA, USA., Zhang D; Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Xu S; Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Greenland P; Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.; Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. |
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| Jazyk: | angličtina |
| Zdroj: | Vascular medicine (London, England) [Vasc Med] 2024 Dec; Vol. 29 (6), pp. 640-652. Date of Electronic Publication: 2024 Sep 06. |
| DOI: | 10.1177/1358863X241268893 |
| Abstrakt: | Background: Mitochondrial abnormalities exist in lower-extremity peripheral artery disease (PAD), yet the association of the ankle-brachial index (ABI) with mitochondrial respiration in gastrocnemius muscle is unknown. The association of gastrocnemius mitochondrial respiration with 6-minute walk distance in PAD is unknown. This objective of this study was to describe associations of the ABI with mitochondrial respiratory function in gastrocnemius muscle biopsies and associations of gastrocnemius mitochondrial respirometry with 6-minute walk distance in people with and without PAD. Methods: People with (ABI ⩽ 0.90) and without (ABI 1.00-1.40) PAD were enrolled. ABI and 6-minute walk distance were measured. Mitochondrial function of permeabilized myofibers from gastrocnemius biopsies was measured with high-resolution respirometry. Results: A total of 30 people with PAD (71.7 years, mean ABI: 0.64) and 68 without PAD (71.8 years, ABI: 1.17) participated. In non-PAD participants, higher ABI values were associated significantly with better mitochondrial respiration (Pearson correlation for maximal oxidative phosphorylation P Conclusions: Major differences exist between people with and without PAD in the association of gastrocnemius mitochondrial respiration with ABI and 6-minute walk distance. Among people without PAD, ABI and walking performance were positively associated with mitochondrial respiratory function. These associations were not observed in PAD. Competing Interests: Declaration of conflicting interestsThe authors declared the following potential conflicts of interest with respect to the research, authorship, and/or publication of this article: Dr. McDermott has received research support from Helixmith, Mars, and ArtAssist. The other authors have no conflicts of interest. |
| Databáze: | MEDLINE |
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