Synchronous Anal Squamous Cell Carcinoma and Diffuse Large B Cell Lymphoma of Stomach: the First Report of an Odd Couple.

Autor: Nath J; Department of Radiation Oncology, Dr. B. Borooah Cancer Institute, Guwahati, Assam 781016 India., Neog M; Department of Radiation Oncology, Dr. B. Borooah Cancer Institute, Guwahati, Assam 781016 India., Iqbal A; Department of Haemato Oncology, Dr. B. Borooah Cancer Institute, Guwahati, India., Sarma A; Department of Oncopathology, Dr. B. Borooah Cancer Institute, Guwahati, India., Khanikar D; Department of Medical Oncology, Dr. B. Borooah Cancer Institute, Guwahati, India., M L A; Department of Pathology, BGS MCH Medical College, Bengaluru, India.
Jazyk: angličtina
Zdroj: Indian journal of surgical oncology [Indian J Surg Oncol] 2024 Sep; Vol. 15 (3), pp. 457-462. Date of Electronic Publication: 2024 Mar 19.
DOI: 10.1007/s13193-024-01927-9
Abstrakt: The unique case study presented here explores an exceptionally rare occurrence in an HIV-positive female-synchronous diagnoses of anal squamous cell carcinoma and diffuse large B cell lymphoma (DLBCL) of the stomach. With limited existing literature on such clinical scenarios, this case serves as an unprecedented insight into the complexities of managing such synchronous malignancies in HIV-positive patients. The article also examines the heightened risk of specific cancer types in individuals living with HIV compared to those without the virus, focusing on AIDS-defining cancers such as Kaposi sarcoma, various lymphomas (including Burkitt lymphoma, immunoblastic lymphoma, and primary central nervous system lymphoma), and invasive cervical cancer. Additionally, it highlights an increased incidence and severity of other cancers amongst HIV-positive individuals, including Hodgkin lymphoma, anal cancer, testicular cancer, melanoma, various skin and superficial eye cancers, and leiomyosarcoma. The article discusses the challenges in the treatment plan, the impact of HIV status on the patient's condition, and the evolving landscape of cancer risk in people living with HIV. Despite significant progress in HIV care, cancer remains a paramount health concern for this population, necessitating tailored approaches and further research to ensure improved outcomes for individuals facing this dual challenge. The case highlights the need for greater inclusivity of PLWH in cancer clinical trials and reinforces the importance of equitable cancer care for this unique patient demographic.
Competing Interests: Competing InterestsThe authors declare no competing interests.
(© The Author(s), under exclusive licence to Indian Association of Surgical Oncology 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.)
Databáze: MEDLINE
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