Inflammatory bowel disease burden in the Middle East and North Africa Region: a comprehensive analysis of incidence, prevalence, and mortality from 1990-2019.

Autor:	Alsakarneh S; Department of Medicine, University of Missouri-Kansas City, Kansas City, MO, USA (Saqr Alsakarneh, Fouad Jaber)., Ahmed M; Department of Gastroenterology and Hepatology, University of Missouri-Kansas City, Kansas City, MO, USA (Mohamed Ahmed)., Jaber F; Department of Medicine, University of Missouri-Kansas City, Kansas City, MO, USA (Saqr Alsakarneh, Fouad Jaber)., Abuassi M; Department of Medicine, University of Central Florida, Gainesville, FL, USA (Mohammad Abuassi)., Mourad FH; Department of Gastroenterology and Hepatology, American University of Beirut, Lebanon (Fadi H. Mourad, Kassem Barada, Rami Tfayli)., Francis FF; Department of Gastroenterology and Hepatology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA (Fadi F. Francis)., Barada K; Department of Gastroenterology and Hepatology, American University of Beirut, Lebanon (Fadi H. Mourad, Kassem Barada, Rami Tfayli)., Tfayli R; Department of Gastroenterology and Hepatology, American University of Beirut, Lebanon (Fadi H. Mourad, Kassem Barada, Rami Tfayli)., Al-Bawardy B; Department of Medicine, Division of Gastroenterology and Hepatology, King Faisal Specialist Hospital, Riyadh, Saudi Arabia (Badr Al-Bawardy).; College of Medicine, Alfaisal University, Riyadh, Saudi Arabia (Badr Al-Bawardy).; Department of Medicine, Section of Digestive Diseases, Yale School of Medicine New Haven, CT, USA (Badr Al-Bawardy)., Farraye FA; Department of Gastroenterology and Hepatology, Mayo Clinic, Jacksonville, FL, USA (Francis A. Farraye, Jana G. Hashash)., Hashash JG; Department of Gastroenterology and Hepatology, Mayo Clinic, Jacksonville, FL, USA (Francis A. Farraye, Jana G. Hashash).
Jazyk:	angličtina
Zdroj:	Annals of gastroenterology [Ann Gastroenterol] 2024 Sep-Oct; Vol. 37 (5), pp. 527-535. Date of Electronic Publication: 2024 Aug 19.
DOI:	10.20524/aog.2024.0909
Abstrakt:	Background: The epidemiology of inflammatory bowel disease (IBD) has changed rapidly in recent years. Objective data concerning the IBD burden in the Middle East and North Africa (MENA) region is limited. We aimed to provide a systematic report on the IBD burden in the MENA region. Additionally, we aimed to study the age- and sex-specific trends in IBD incidence, prevalence and mortality rates from 1990-2019. Methods: Using the Global Burden of Disease (GBD) 2019 Study Database, we investigated the changes in incidence, prevalence and mortality rate, and disability-adjusted life-years (DALYs), at a regional and country level between 1990 and 2019. Results: In 2019, there were 282,534 cases (95% confidence interval [CI] 239,506-334,478) of IBD in the MENA region (50.5% male). There was an overall increase in the incidence and prevalence rates of IBD in the MENA region from 1990 to 2019, while a simultaneous decrease in overall mortality rates was identified. Incidence rates were highest in Jordan, at 6.9 (95%CI 5.8-8.1) per 100,000, and lowest in Morocco, at 1.6 (95%CI 1.4-2) per 100,000. From 1990-2019, the incidence was found increased in males at a higher rate than in females. The age-standardized mortality rate decreased for both sexes by 24% from 1990-2019. Conclusion: The trends and geographic variations in IBD within the MENA region provide policymakers with vital information for making informed decisions in policy, research, and investment, thereby enabling the development of more effective strategies and better allocation of resources. Competing Interests: Conflict of Interest: FAF: AbbVie, Avalo Therapeutics, BMS, Braintree Labs, Fresenius Kabi, GI Reviewers, GSK, IBD Educational Group, Iterative Health, Janssen, Pharmacosmos, Pfizer, Sandoz Immunology, Sebela, Viatris. DSMB: Lilly. JGH: Advisory Board for BMS. Other authors have no conflict of interest (Copyright: © 2024 Hellenic Society of Gastroenterology.)
Databáze:	MEDLINE
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