Exploring the link between chromosomal polymorphisms and reproductive abnormalities.

Autor: Pang H; Department of Reproductive Medicine, Affiliated Hospital of Shandong Second Medical University, Weifang, Shandong, China., Zhang T; Department of Reproductive Medicine, Affiliated Hospital of Shandong Second Medical University, Weifang, Shandong, China., Yi X; Department of Reproductive Medicine, Affiliated Hospital of Shandong Second Medical University, Weifang, Shandong, China., Cheng X; Department of Reproductive Medicine, Affiliated Hospital of Shandong Second Medical University, Weifang, Shandong, China., Wang G; Department of Reproductive Medicine, Affiliated Hospital of Shandong Second Medical University, Weifang, Shandong, China. wangguiling666@sina.com.
Jazyk: angličtina
Zdroj: Reproductive health [Reprod Health] 2024 Sep 05; Vol. 21 (1), pp. 130. Date of Electronic Publication: 2024 Sep 05.
DOI: 10.1186/s12978-024-01854-6
Abstrakt: Objective: This work aimed to investigate the potential correlation between chromosomal polymorphisms and various reproductive abnormalities.
Methods: We examined 21,916 patients affected by infertility who sought care at the Department of Reproductive Medicine, Affiliated Hospital of Shandong Second Medical University between January 2018 and December 2022. A total of 2227 individuals identified as chromosomal polymorphism carriers constituted the polymorphism group, and 2245 individuals with normal chromosome karyotypes were randomly selected to form a control group. Clinical manifestations, histories of spontaneous miscarriage, abnormal reproductive developments, fetal abnormalities, and male sperm quality anomalies were statistically compared between these two groups.
Results: Of the 21,916 patients analyzed, 2227 displayed chromosomal polymorphism, representing a 10.16% detection rate. Amongst the male patients, 1622 out of 10,827 exhibited polymorphisms (14.98%), whereas 605 out of 11,089 females showed polymorphisms (5.46%). Female carriers in the polymorphism group, showed statistically significant increased rates of spontaneous abortion (29.75% vs. 18.54%), fetal anomalies (1.32% vs. 0.81%), and uterine abnormalities compared with the control group (1.32% vs. 0.81%). Male carriers in the polymorphism group had higher rates of spontaneous abortion in partners (22.87% vs. 10.37%), fetal anomalies (1.97% vs. 0.25%), compromised sperm quality (41.74% vs. 7.18%), testicular underdevelopment (2.28% vs. 0.92%), and hypogonadotropic hypogonadism (0.62% vs. 0.37%) compared with the control group.
Conclusion: Chromosomal polymorphisms may have a certain negative effect on reproductive irregularities, including spontaneous abortions, fetal anomalies, and reduced sperm quality in males. Their clinical effects deserve further investigation.
(© 2024. The Author(s).)
Databáze: MEDLINE
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