Exploring the role of calf circumference as a predisposing factor for intra-hospital delirium: investigating potential gender differences: revealing potential gender variances.

Autor: Ceolin C; Department of Medicine (DIMED) Geriatrics Division, University of Padua, Via Giustiniani 2, Padua, 35128, Italy. chiara.ceolin.1@phd.unipd.it.; Department of Neurobiology, Care Sciences and Society, Aging Research Center, Karolinska Institutet and Stockholm University, Stockholm, Sweden. chiara.ceolin.1@phd.unipd.it., Papa MV; Department of Medicine (DIMED) Geriatrics Division, University of Padua, Via Giustiniani 2, Padua, 35128, Italy., Simonato C; Department of Medicine (DIMED) Geriatrics Division, University of Padua, Via Giustiniani 2, Padua, 35128, Italy., Cazzavillan S; Department of Medicine (DIMED) Geriatrics Division, University of Padua, Via Giustiniani 2, Padua, 35128, Italy., Vergadoro M; Department of Medicine (DIMED), Department of Women's and Children's Health, University of Padua, Padua, Italy., Trapella GS; Department of Medicine (DIMED) Geriatrics Division, University of Padua, Via Giustiniani 2, Padua, 35128, Italy., Sermasi R; Department of Medicine (DIMED) Geriatrics Division, University of Padua, Via Giustiniani 2, Padua, 35128, Italy., De Rui M; Department of Medicine (DIMED) Geriatrics Division, University of Padua, Via Giustiniani 2, Padua, 35128, Italy., Noale M; Neuroscience Institute, National Research Council, Padua, Italy., Zanforlini BM; Department of Medicine (DIMED) Geriatrics Division, University of Padua, Via Giustiniani 2, Padua, 35128, Italy., Curreri C; Department of Medicine (DIMED) Geriatrics Division, University of Padua, Via Giustiniani 2, Padua, 35128, Italy., Bertocco A; Department of Medicine (DIMED) Geriatrics Division, University of Padua, Via Giustiniani 2, Padua, 35128, Italy., Devita M; Department of Medicine (DIMED) Geriatrics Division, University of Padua, Via Giustiniani 2, Padua, 35128, Italy.; Department of General Psychology (DPG), University of Padua, Padua, Italy., Sergi G; Department of Medicine (DIMED) Geriatrics Division, University of Padua, Via Giustiniani 2, Padua, 35128, Italy., Coin A; Department of Medicine (DIMED) Geriatrics Division, University of Padua, Via Giustiniani 2, Padua, 35128, Italy.
Jazyk: angličtina
Zdroj: BMC geriatrics [BMC Geriatr] 2024 Sep 05; Vol. 24 (1), pp. 739. Date of Electronic Publication: 2024 Sep 05.
DOI: 10.1186/s12877-024-05334-1
Abstrakt: Background: Malnutrition and sarcopenia significantly increase the risk of intra-hospital delirium, particularly among older adults. Given the potential correlation between calf circumference (CC) and these conditions, CC emerges as a promising predisposing factor for delirium. This study aims to investigate the independent association between delirium and anthropometric parameters, focusing on evaluating CC's predictive capacity for intra-hospital delirium risk. Additionally, it aims to compare CC's predictive performance with the widely used Mini Nutritional Assessment (MNA), while also considering potential gender disparities.
Methods: This is a retrospective study which enrolled patients aged ≥ 65 years from September 2021 to March 2022 at the Padova Hospital (Italy). Physical characteristics, intra-hospital delirium incidence, and body composition were assessed. Sarcopenia was diagnosed using the 2019 European Consensus criteria.
Results: Among 207 subjects, delirium affected 19% of patients. CC showed a significant association with intra-hospital delirium among the analyzed anthropometric parameters. ROC curves indicated that CC's predictive capacity for delirium onset was comparable to MNA (p = 0.98), particularly in women. In a multivariable logistic regression model, female gender and higher cognitive and CC scores emerged as protective factors against delirium onset, with each unit increase in CC associated with a 24% reduction in the odds of delirium. Conversely, sarcopenia did not significantly influence delirium onset.
Conclusions: CC shows promise as a predisposing factor for intra-hospital delirium, similar to MNA, albeit with significant gender differences. CC could serve as a valuable tool for assessing delirium risk among female patients. Further validation of these findings is necessary through larger-scale studies.
(© 2024. The Author(s).)
Databáze: MEDLINE
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