Cocos nucifera and glycerine afterwork moisturizers for secondary prevention of hand dermatitis among fabric worker: a randomized, double-blind, cross over trial.

Autor: Budianti WK; Dermato-venereology Department, Faculty of Medicine, Universitas Indonesia, Depok, Indonesia. wkeumala@gmail.com., Soebaryo RW; Dermato-venereology Department, Faculty of Medicine, Universitas Indonesia, Depok, Indonesia., Mansyur M; Occupational Medicine Department, Faculty of Medicine, Universitas Indonesia, Depok, Indonesia., Suyatna FD; Clinical Pharmacology Department, Faculty of Medicine, Universitas Indonesia, Depok, Indonesia., Siagian M; Physiology Department, Faculty of Medicine, Universitas Indonesia, Depok, Indonesia., Djajadisastra J; Faculty of Pharmacy, Universitas Indonesia, Depok, Indonesia., Prakoeswa CRS; Faculty of Medicine, Airlangga University, Depok, Indonesia.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2024 Sep 05; Vol. 14 (1), pp. 20702. Date of Electronic Publication: 2024 Sep 05.
DOI: 10.1038/s41598-024-72010-0
Abstrakt: The use of skin barrier-enhancing topical medication is a favorable approach for the treatment of occupational hand dermatitis (OHD). Cocos nucifera or coconut oil is one of the best sources of lipid enriched with laurate acid, and glycerin is a well-known humectant that improves skin hydration. This study is aimed is to evaluate the effectiveness of C. nucifera and glycerin for secondary prevention of OHD among batik (Indonesian traditional fabric) workers. In a randomized, double-blind, crossover trial, the effect of glycerine-C. nucifera cream versus glycerin-only was considered with multiple afterwork applications of moisturizer over a 2-week period on batik workers with OHD. Assessment of trans-epidermal water loss (TEWL), skin capacitance, and a clinical assessment using the Hand Eczema Severity Index (HECSI) were carried out at day 0 and 14. The results show thirty-two batik dyeing and/or rinsing workers were enrolled in the study with mild to moderate OHD. Clinical improvement was demonstrated by 20% decrease in HECSI and TEWL, and 20% increase in skin capacitance. Both moisturizers were equally effective for the secondary prevention of OHD. As a conclusion, glycerine-C. nucifera and glycerin-only cream are equally effective for secondary prevention for OHD among batik worker to reduce the prevalence of hand dermatitis.
(© 2024. The Author(s).)
Databáze: MEDLINE
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