Impact of Obesity on Breast Cancer Clinicopathological Characteristics in Underserved US Community Safety-Net Hospital: A Retrospective Single-Center Study.

Autor: Proskuriakova E; Department of Internal Medicine, Mount Sinai Hospital, Chicago, IL. Electronic address: ekaterinaproskuriakova@gmail.com., Aryal BB; Department of Internal Medicine, Mount Sinai Hospital, Chicago, IL., Shrestha DB; Department of Internal Medicine, Mount Sinai Hospital, Chicago, IL., Valencia S; Department of Internal Medicine, Mount Sinai Hospital, Chicago, IL., Kovalenko I; Department of Internal Medicine, UPMC Harrisburg, Harrisburg, PA., Adams M; Department of Internal Medicine, Ross University School of Medicine, Michael, Barbados., Boxwala M; Department of Internal Medicine, Ross University School of Medicine, Michael, Barbados., Verda L; Department of Internal Medicine, Mount Sinai Hospital, Chicago, IL., Khosla PG; Department of Hematology & Oncology, Mount Sinai Hospital, Chicago, IL.
Jazyk: angličtina
Zdroj: Clinical breast cancer [Clin Breast Cancer] 2024 Dec; Vol. 24 (8), pp. e714-e722. Date of Electronic Publication: 2024 Aug 13.
DOI: 10.1016/j.clbc.2024.08.008
Abstrakt: Background: Breast cancer continues to pose a significant public health challenge, with its incidence and disproportionate impact on underserved populations in the United States. The relationship between obesity and clinicopathological characteristics at presentation remains a critical area of investigation. Safety-net hospitals caring for underserved communities provide a unique setting to explore these associations. This study seeks to explore a critical gap in knowledge on obesity and breast cancer characteristics in underserved populations in the United States.
Materials and Methods: In this retrospective study, 927 breast cancer patients were included. Analysis was conducted to assess the association between body mass index (BMI), age of diagnosis, tumor clinicopathologic characteristics, and molecular types stratified by menopausal status at diagnosis. Analysis was performed using the Statistical Package for Social Sciences version 29.
Results: A significant association was found between BMI and menopausal status (P < .05). Disease stage at presentation was significantly associated with BMI (P < .05). Further investigation into BMI categories and tumor characteristics revealed a significant correlation in postmenopausal women, with obesity linked to tumor size and lymph node status (P < .05). No significant associations were observed between HER-2 status, ER/PR status, and obesity in either premenopausal or postmenopausal groups.
Conclusion: This observational retrospective hypothesis-generating study revealed the association between obesity and disease stage and menopause status at diagnosis. In postmenopausal patients, obesity correlated with larger tumor size and advanced lymph node disease involvement. Additionally, ethnic variations were observed, with a higher prevalence of obesity among African American patients.
Competing Interests: Disclosure The authors have stated that they have no conflicts of interest.
(Copyright © 2024 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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