Physical activity and prognosis and factors associated with low physical activity in patients with advanced or recurrent lung cancer: a retrospective, observational study.

Autor:	Fukushima T; Faculty of Rehabilitation, Kansai Medical University, Hirakata, Osaka, Japan., Katsushima U; Department of Thoracic Oncology, Kansai Medical University, Hirakata, Osaka, Japan., Ogushi N; Department of Rehabilitation, Kansai Medical University Hospital, Hirakata, Osaka, Japan., Hase K; Department of Physical Medicine & Rehabilitation, Kansai Medical University, Hirakata, Osaka, Japan., Nakano J; Faculty of Rehabilitation, Kansai Medical University, Hirakata, Osaka, Japan nakanoj@hirakata.kmu.ac.jp.
Jazyk:	angličtina
Zdroj:	BMJ supportive & palliative care [BMJ Support Palliat Care] 2024 Sep 05. Date of Electronic Publication: 2024 Sep 05.
DOI:	10.1136/spcare-2024-005122
Abstrakt:	Objectives: To investigate the relationship between physical activity and prognosis, and the significant factors associated with physical activity in patients with advanced or recurrent lung cancer. Methods: This retrospective, observational study enrolled 50 outpatients with lung cancer who received chemotherapy. Patients were evaluated for physical function, physical activity (International Physical Activity Questionnaire-Short Form), and nutritional status (Mini Nutritional Assessment-Short Form [MNA-SF]). The relationship between physical activity and prognosis was examined using the log-rank test and Cox proportional hazards model. Multivariate logistic regression analysis was performed to examine factors associated with low physical activity. A receiver operating characteristic curve was used to calculate the MNA-SF cut-off value for low physical activity. Results: Low physical activity was significantly associated with survival (HR, 4.35; 95% confidence interval [CI], 1.16-16.27; p=0.029). The MNA-SF was a significant factor associated with low physical activity (OR, 0.71; 95% CI, 0.52 to 0.98; p=0.038). The MNA-SF cut-off value for low physical activity was 9.5 points. Conclusions: Low physical activity may be a prognostic factor in lung cancer, with nutritional status associated with low physical activity. Regular assessments using the MNA-SF cut-off and physical activity interventions considering nutrition are needed in clinical practice. Competing Interests: Competing interests: The authors declare no potential conflicts of interest with respect to the research, authorship or publication of this article. (© Author(s) (or their employer(s)) 2024. No commercial re-use. See rights and permissions. Published by BMJ.)
Databáze:	MEDLINE
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