Disturbances of thalamus and prefrontal cortex contribute to cognitive aging: A structure-function coupling analysis based on KL divergence.

Autor: Cao W; School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 611731, China; Institute of Electronic and Information Engineering of Guangdong, University of Electronic Science and Technology of China, Dongguan 523000, China; School of Radiology, Shandong First Medical University & Shandong Academy of Medical Sciences, Tai'an 271016, China., Niu J; School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 611731, China; School of Radiology, Shandong First Medical University & Shandong Academy of Medical Sciences, Tai'an 271016, China., Liang Y; Institute of Electronic and Information Engineering of Guangdong, University of Electronic Science and Technology of China, Dongguan 523000, China., Cui D; School of Radiology, Shandong First Medical University & Shandong Academy of Medical Sciences, Tai'an 271016, China., Jiao Q; School of Radiology, Shandong First Medical University & Shandong Academy of Medical Sciences, Tai'an 271016, China., Ouyang Z; School of Radiology, Shandong First Medical University & Shandong Academy of Medical Sciences, Tai'an 271016, China., Yu G; School of Radiology, Shandong First Medical University & Shandong Academy of Medical Sciences, Tai'an 271016, China., Dong L; School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 611731, China., Luo C; School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 611731, China. Electronic address: chengluo@uestc.edu.cn.
Jazyk: angličtina
Zdroj: Neuroscience [Neuroscience] 2024 Nov 01; Vol. 559, pp. 263-271. Date of Electronic Publication: 2024 Sep 03.
DOI: 10.1016/j.neuroscience.2024.09.004
Abstrakt: Normal aging is accompanied by changes in brain structure and function associated with cognitive decline. Structural and functional abnormalities, particularly the prefrontal cortex (PFC) and subcortical regions, contributed to cognitive aging. However, it remains unclear how the synchronized changes in structure and function of individual brain regions affect the cognition in aging. Using 3D T1-weighted structural data and movie watching functional magnetic resonance imaging data in a sample of 422 healthy individuals (ages from 18 to 87 years), we constructed regional structure-function coupling (SFC) of cortical and subcortical regions by quantifying the distribution similarity of gray matter volume (GMV) and amplitude of low-frequency fluctuation (ALFF). Further, we investigated age-related changes in SFC and its relationship with cognition. With aging, increased SFC localized in PFC, thalamus and caudate nucleus, decreased SFC in temporal cortex, lateral occipital cortex and putamen. Moreover, the SFC in the PFC was associated with executive function and thalamus was associated with the fluid intelligence, and partially mediated age-related cognitive decline. Collectively, our results highlight that tighter structure-function synchron of the PFC and thalamus might contribute to age-related cognitive decline, and provide insight into the substrate of the thalamo-prefrontal pathway with cognitive aging.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 International Brain Research Organization (IBRO). Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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