Versatile system cores as a conceptual basis for generality in cell and developmental biology.

Autor:	Gallo E; Institute of Molecular Life Sciences, University of Zurich (UZH), 8057 Zurich, Switzerland., De Renzis S; Developmental Biology Unit, European Molecular Biology Laboratory (EMBL), 69117 Heidelberg, Germany., Sharpe J; EMBL Barcelona, European Molecular Biology Laboratory (EMBL), 08003 Barcelona, Spain; Institució Catalana de Recerca i Estudis Avançats, 08010 Barcelona, Spain., Mayor R; Department of Cell and Developmental Biology, University College London, London WC1E 6BT, UK., Hartmann J; Institute of Molecular Life Sciences, University of Zurich (UZH), 8057 Zurich, Switzerland; Developmental Biology Unit, European Molecular Biology Laboratory (EMBL), 69117 Heidelberg, Germany; EMBL Barcelona, European Molecular Biology Laboratory (EMBL), 08003 Barcelona, Spain; Department of Cell and Developmental Biology, University College London, London WC1E 6BT, UK; Northwestern Institute on Complex Systems, Northwestern University, Evanston, IL 60208, USA; Department of Chemical and Biological Engineering, Northwestern University, Evanston, IL 60208, USA. Electronic address: jonas.hartmann@ucl.ac.uk.
Jazyk:	angličtina
Zdroj:	Cell systems [Cell Syst] 2024 Sep 18; Vol. 15 (9), pp. 790-807. Date of Electronic Publication: 2024 Sep 04.
DOI:	10.1016/j.cels.2024.08.001
Abstrakt:	The discovery of general principles underlying the complexity and diversity of cellular and developmental systems is a central and long-standing aim of biology. While new technologies collect data at an ever-accelerating rate, there is growing concern that conceptual progress is not keeping pace. We contend that this is due to a paucity of conceptual frameworks that support meaningful generalizations. This led us to develop the core and periphery (C&P) hypothesis, which posits that many biological systems can be decomposed into a highly versatile core with a large behavioral repertoire and a specific periphery that configures said core to perform one particular function. Versatile cores tend to be widely reused across biology, which confers generality to theories describing them. Here, we introduce this concept and describe examples at multiple scales, including Turing patterning, actomyosin dynamics, multi-cellular morphogenesis, and vertebrate gastrulation. We also sketch its evolutionary basis and discuss key implications and open questions. We propose that the C&P hypothesis could unlock new avenues of conceptual progress in mesoscale biology. Competing Interests: Declaration of interests The authors declare no competing interests. (Copyright © 2024 The Author(s). Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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