Serum uric acid and pulmonary arterial hypertension: A two-sample Mendelian randomization study.

Autor: Tan Y; Department of Cardiology, The Second Xiangya Hospital of Central South University, Changsha, China., Chen Y; Department of Cardiology, The Second Xiangya Hospital of Central South University, Changsha, China., Wang T; Department of Cardiology, The Second Xiangya Hospital of Central South University, Changsha, China., Li J; Department of Cardiology, The Second Xiangya Hospital of Central South University, Changsha, China. Electronic address: lijiangcs@csu.edu.cn.
Jazyk: angličtina
Zdroj: Heart & lung : the journal of critical care [Heart Lung] 2024 Nov-Dec; Vol. 68, pp. 337-341. Date of Electronic Publication: 2024 Sep 04.
DOI: 10.1016/j.hrtlng.2024.08.018
Abstrakt: Background: Observational studies have suggested a correlation between hyperuricemia and pulmonary arterial hypertension (PAH), yet the causal relationship remains uncertain. We aimed to establish this link using Mendelian Randomization (MR) methods.
Objectives: Based on publicly accessible data, our study employs MR to determine the causal relationship between uric acid (UA) and PAH.
Method: MR analysis was conducted among individuals of European descent. Genetic instruments linked to UA (p-value < 5 × 10 -8 ) were extracted from the Chronic Kidney Disease Genetic Consortium and genome-wide association study databases. PAH risk genetic associations were sourced separately. We employed four MR methods (MR-Egger, weighted median, inverse variance weighted, and weighted mode) with selected instrumental variables to assess the causal association between UA and PAH. MR-PRESSO was used to evaluate pleiotropy and outlier Single Nucleotide Polymorphisms (SNPs), while Cochran's Q test and funnel plot assessed SNP heterogeneity. Leave-one-out analysis examined SNP impacts on causal assessment.
Result: Two-sample MR analysis revealed a positive, causal relationship between UA levels and PAH.
Conclusion: Our MR analysis provides robust evidence of a causal link between serum UA and PAH, suggesting UA's potential as a biomarker and therapeutic target for PAH.
Competing Interests: Declaration of competing interest The authors declare that there are no financial interests or personal relationships that could have appeared to influence the work reported in this paper. All authors have contributed to this research and concur with the content of the manuscript.
(Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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