Association between insulin-like growth factor-1 and ocular surface parameters in obese prepubertal boys.

Autor: Jiang W; Institute of Medical Sciences, The Second Hospital of Shandong University, Jinan, Shandong, China., Yang L; Department of Ophthalmology, The Second Hospital of Shandong University, Jinan, Shandong, China. 15153169515@163.com., Liang S; Department of Pediatrics, The Second Hospital of Shandong University, 247 Beiyuan Main Street, Jinan, 250021, Shandong, China. liangshuang3508@163.com.
Jazyk: angličtina
Zdroj: European journal of pediatrics [Eur J Pediatr] 2024 Nov; Vol. 183 (11), pp. 4807-4816. Date of Electronic Publication: 2024 Sep 05.
DOI: 10.1007/s00431-024-05748-4
Abstrakt: The study aimed to investigate the correlation between insulin-like growth factor 1 (IGF-1) and ocular surface parameters in obese prepubertal boys. Thirty obese prepubertal boys and 30 age- and gender-matched healthy controls underwent physical measurements, laboratory tests, and ocular surface assessments. The obese group showed lower IGF-1 levels (P = 0.001), reduced Schirmer I tear test (SIT) (P <0.001), and higher meibomian gland scores (meiboscore) compared to controls (P = 0.015). Bivariate analysis revealed a positive association between IGF-1 and SIT (r = 0.677, P < 0.001), and a negative association with between IGF-1 and meiboscore (r =  - 0.487, P < 0.001). Multiple regression analysis indicated that IGF-1 (P < 0.001) and triglycerides (P = 0.028) independently influenced SIT. Logistic analysis showed a significant association between decreased IGF-1 and higher meiboscore values (OR 0.994, 95% confidence interval 0.988-1.000; P = 0.033).
Conclusion: The findings suggest that reduced IGF-1 in obese prepubertal boys is independently linked to decreased SIT and increased meiboscore, irrespective of obesity and traditional cardiovascular risk factors. This implies that monitoring ocular surface parameters in obese children might provide a new perspective for clinical practice to focus on.
What Is Known: • Obese children exhibit decreased levels of IGF-1, and this reduction in IGF-1 is associated with cardiovascular metabolic complications related to obesity. • Ocular surface tissues might act as targets for hormones, might experience local effects of these hormone.
What Is New: • In prepubertal obese boys, the decrease in IGF-1 is independently linked to decreased SIT and increased meiboscore, irrespective of obesity and traditional cardiovascular risk factors. • This finding implies that monitoring ocular surface parameters in obese children might provide a new perspective for clinical practice to focus on.
(© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
Databáze: MEDLINE
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