Facile Size Tunable Skin-Adaptive Patch for Accelerating Wound Healing.

Autor: Kim SW; School of Chemical Engineering, Sungkyunkwan University, Suwon, 16419, Republic of Korea.; Department of Orthopaedic Surgery, Stanford University School of Medicine, Stanford, CA, 94305, USA., Baik S; School of Mechanical Engineering, Sungkyunkwan University, Suwon, 16419, Republic of Korea., Hyun J; School of Chemical Engineering, Sungkyunkwan University, Suwon, 16419, Republic of Korea., Lee J; School of Chemical Engineering, Sungkyunkwan University, Suwon, 16419, Republic of Korea., Lim D; School of Chemical Engineering, Sungkyunkwan University, Suwon, 16419, Republic of Korea., Lee TJ; Department of Medical Biotechnology, Division of Biomedical Convergence, College of Biomedical Science, Kangwon National University, Chuncheon-si, 24341, Republic of Korea., Jeong GJ; Institute of Cell and Tissue Engineering, College of Medicine, The Catholic University of Korea, Seoul, 06591, Republic of Korea., Im GB; School of Chemical Engineering, Sungkyunkwan University, Suwon, 16419, Republic of Korea.; Department of Cardiac Surgery, Boston Children's Hospital, Boston, MA, 02115, USA., Seo I; School of Chemical Engineering, Sungkyunkwan University, Suwon, 16419, Republic of Korea., Kim YH; School of Chemical Engineering, Sungkyunkwan University, Suwon, 16419, Republic of Korea.; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, 10032, USA., Pang C; School of Chemical Engineering, Sungkyunkwan University, Suwon, 16419, Republic of Korea., Bhang SH; School of Chemical Engineering, Sungkyunkwan University, Suwon, 16419, Republic of Korea.
Jazyk: angličtina
Zdroj: Advanced healthcare materials [Adv Healthc Mater] 2024 Nov; Vol. 13 (29), pp. e2304435. Date of Electronic Publication: 2024 Sep 05.
DOI: 10.1002/adhm.202304435
Abstrakt: Owing to the moist and curved interfaces of skin wounds, enhancing the adhesiveness while maintaining delivery efficacy of biomolecules has drawn significant attention in advanced wound dressings. Despite tremendous trials to load biomolecules with sound adhesiveness, the complicated fabricating processes and abnormal allergic responses that are attributed to chemical moiety-based adhesives remain as major problems. To this end, in this study a one-step fabrication process is developed to manufacture microstructures with both a therapeutic (cylindrical structure for embossed structure human adipose-derived stem cell sheet, ESS) and an adhesive part (octopi-inspired structure of adhesive, OIA), which ESOIA is called. OIA showed the highest adhesion strength in both dry (1.48 N cm -2 ) and wet pig skin conditions (0.81 N cm -2 ), maintaining the adhesive properties after repeated attach-detach trials. ESS from the therapeutic part of ESOIA also showed an enhanced angiogenic effect compared with the ones that are normally cultured in vitro. ESS also showed improved in vivo wound healing outcomes following enhanced cell engraftment compared to the cell injection group by means of intact cell-extracellular matrix interactions.
(© 2024 Wiley‐VCH GmbH.)
Databáze: MEDLINE
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