A Novel Expression Domain of extradenticle Underlies the Evolutionary Developmental Origin of the Chelicerate Patella.

Autor:	Klementz BC; Department of Integrative Biology, University of Wisconsin-Madison, Madison, WI, USA.; University of Wisconsin-Madison Zoological Museum, University of Wisconsin-Madison, Madison, WI, USA., Brenneis G; Unit Integrative Zoologie, Department Evolutionsbiologie, Universität Wien, Vienna, Austria., Hinne IA; Department of Biochemistry and Molecular Biology, University of Nevada, Reno, NV, USA., Laumer EM; Department of Integrative Biology, University of Wisconsin-Madison, Madison, WI, USA.; University of Wisconsin-Madison Zoological Museum, University of Wisconsin-Madison, Madison, WI, USA., Neu SM; Department of Integrative Biology, University of Wisconsin-Madison, Madison, WI, USA.; University of Wisconsin-Madison Zoological Museum, University of Wisconsin-Madison, Madison, WI, USA., Hareid GM; Department of Integrative Biology, University of Wisconsin-Madison, Madison, WI, USA.; University of Wisconsin-Madison Zoological Museum, University of Wisconsin-Madison, Madison, WI, USA., Gainett G; Department of Integrative Biology, University of Wisconsin-Madison, Madison, WI, USA.; Department of Systems Biology, Harvard Medical School, Boston, MA, USA.; Department of Pathology, Boston Children,'s Hospital, Boston, MA, USA., Setton EVW; Department of Integrative Biology, University of Wisconsin-Madison, Madison, WI, USA.; Department of Ecology and Evolutionary Biology, Cornell University, Ithaca, NY, USA., Simian C; Laboratorio de Biología Reproductiva y Evolución, Instituto de Diversidad y Ecología Animal (IDEA), Consejo Nacional de Investigaciones Cientifícas Técnicas (CONICET), Universidad Nacional de Córdoba, Córdoba, Argentina., Vrech DE; Laboratorio de Biología Reproductiva y Evolución, Instituto de Diversidad y Ecología Animal (IDEA), Consejo Nacional de Investigaciones Cientifícas Técnicas (CONICET), Universidad Nacional de Córdoba, Córdoba, Argentina., Joyce I; Department of Biology, DeSales University, Center Valley, PA, USA., Barnett AA; Department of Biology, DeSales University, Center Valley, PA, USA., Patel NH; Marine Biological Laboratory, Woods Hole, MA, USA.; Organismal Biology & Anatomy, University of Chicago, Chicago, IL, USA., Harvey MS; Collections & Research, Western Australian Museum, Welshpool, WA, Australia., Peretti AV; Laboratorio de Biología Reproductiva y Evolución, Instituto de Diversidad y Ecología Animal (IDEA), Consejo Nacional de Investigaciones Cientifícas Técnicas (CONICET), Universidad Nacional de Córdoba, Córdoba, Argentina., Gulia-Nuss M; Department of Biochemistry and Molecular Biology, University of Nevada, Reno, NV, USA., Sharma PP; Department of Integrative Biology, University of Wisconsin-Madison, Madison, WI, USA.; University of Wisconsin-Madison Zoological Museum, University of Wisconsin-Madison, Madison, WI, USA.
Jazyk:	angličtina
Zdroj:	Molecular biology and evolution [Mol Biol Evol] 2024 Sep 04; Vol. 41 (9).
DOI:	10.1093/molbev/msae188
Abstrakt:	Neofunctionalization of duplicated gene copies is thought to be an important process underlying the origin of evolutionary novelty and provides an elegant mechanism for the origin of new phenotypic traits. One putative case where a new gene copy has been linked to a novel morphological trait is the origin of the arachnid patella, a taxonomically restricted leg segment. In spiders, the origin of this segment has been linked to the origin of the paralog dachshund-2, suggesting that a new gene facilitated the expression of a new trait. However, various arachnid groups that possess patellae do not have a copy of dachshund-2, disfavoring the direct link between gene origin and trait origin. We investigated the developmental genetic basis for patellar patterning in the harvestman Phalangium opilio, which lacks dachshund-2. Here, we show that the harvestman patella is established by a novel expression domain of the transcription factor extradenticle. Leveraging this definition of patellar identity, we surveyed targeted groups across chelicerate phylogeny to assess when this trait evolved. We show that a patellar homolog is present in Pycnogonida (sea spiders) and various arachnid orders, suggesting a single origin of the patella in the ancestor of Chelicerata. A potential loss of the patella is observed in Ixodida. Our results suggest that the modification of an ancient gene, rather than the neofunctionalization of a new gene copy, underlies the origin of the patella. Broadly, this work underscores the value of comparative data and broad taxonomic sampling when testing hypotheses in evolutionary developmental biology. (© The Author(s) 2024. Published by Oxford University Press on behalf of Society for Molecular Biology and Evolution.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu