Perspective: metabolomics has the potential to change the landscape of kidney transplantation diagnostics.
| Autor: | Kuypers DRJ; Department of Nephrology & Renal Transplantation, University Hospitals Leuven, Belgium.; Department of Microbiology, Immunology & Transplantation, Nephrology & Renal Transplantation Research Group, KU Leuven, Belgium., Kamphorst JJ; Olaris, Inc., Framingham, MA 01702, USA., Loor H; Department of Nephrology & Renal Transplantation, University Hospitals Leuven, Belgium., O'Day EM; Olaris, Inc., Framingham, MA 01702, USA. |
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| Jazyk: | angličtina |
| Zdroj: | Biomarkers in medicine [Biomark Med] 2024; Vol. 18 (17-18), pp. 787-794. Date of Electronic Publication: 2024 Sep 05. |
| DOI: | 10.1080/17520363.2024.2394383 |
| Abstrakt: | Kidney transplantation is the most efficient renal replacement therapy. Current diagnostics for monitoring graft health are either invasive or lack precision. Metabolomics is an emerging discipline focused on the analysis of the small molecules involved in metabolism. Given the kidneys' central role in metabolic homeostasis and previous observations of altered metabolites correlating with restricted kidney graft function, metabolomics is highly promising for the discovery of novel biomarkers and the development of novel diagnostics. In this perspective, we summarize the known metabolic roles for the kidney, discuss biomarkers of graft health and immune status emerging from metabolomics research, and provide our perspective on how these and future findings can be integrated in clinical practice to enable precision diagnostics. |
| Databáze: | MEDLINE |
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