Therapeutic Potential of Terpenoids in Cancer Treatment: Targeting Mitochondrial Pathways.

Autor: Guo J; College of Integrated Chinese and Western Medicine, Hebei Medical University, Shijiazhuang, China., Huang M; College of Integrated Chinese and Western Medicine, Hebei Medical University, Shijiazhuang, China., Hou S; College of Integrated Chinese and Western Medicine, Hebei Medical University, Shijiazhuang, China., Yuan J; College of Integrated Chinese and Western Medicine, Hebei Medical University, Shijiazhuang, China., Chang X; College of Integrated Chinese and Western Medicine, Hebei Medical University, Shijiazhuang, China., Gao S; College of Integrated Chinese and Western Medicine, Hebei Medical University, Shijiazhuang, China., Zhang Z; College of Integrated Chinese and Western Medicine, Hebei Medical University, Shijiazhuang, China., Wu Z; College of Integrated Chinese and Western Medicine, Hebei Medical University, Shijiazhuang, China., Li J; College of Integrated Chinese and Western Medicine, Hebei Medical University, Shijiazhuang, China.; The Fourth Hospital of Hebei Medical University, Shijiazhuang, China.
Jazyk: angličtina
Zdroj: Cancer reports (Hoboken, N.J.) [Cancer Rep (Hoboken)] 2024 Sep; Vol. 7 (9), pp. e70006.
DOI: 10.1002/cnr2.70006
Abstrakt: Background: In recent decades, natural compounds have been considered a significant source of new antitumor medicines due to their unique advantages. Several in vitro and in vivo studies have focused on the effect of terpenoids on apoptosis mediated by mitochondria in malignant cells.
Recent Findings: In this review article, we focused on six extensively studied terpenoids, including sesquiterpenes (dihydroartemisinin and parthenolide), diterpenes (oridonin and triptolide), and triterpenes (betulinic acid and oleanolic acid), and their efficacy in targeting mitochondria to induce cell death. Terpenoid-induced mitochondria-related cell death includes apoptosis, pyroptosis, necroptosis, ferroptosis, autophagy, and necrosis caused by mitochondrial permeability transition. Apoptosis and autophagy interact in meaningful ways. In addition, in view of several disadvantages of terpenoids, such as low stability and bioavailability, advances in research on combination chemotherapy and chemical modification were surveyed.
Conclusion: This article deepens our understanding of the association between terpenoids and mitochondrial cell death, presenting a hypothetical basis for the use of terpenoids in anticancer management.
(© 2024 The Author(s). Cancer Reports published by Wiley Periodicals LLC.)
Databáze: MEDLINE
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