Primary cilia-associated signalling in squamous cell carcinoma of head and neck region.

Autor:	Putnová I; Laboratory of Molecular Morphogenesis, Institute of Animal Physiology and Genetics, Czech Academy of Sciences, Brno, Czechia.; Department of Anatomy, Histology and Embryology, University of Veterinary Sciences Brno, Brno, Czechia., Putnová BM; Laboratory of Molecular Morphogenesis, Institute of Animal Physiology and Genetics, Czech Academy of Sciences, Brno, Czechia.; Department of Pathological Morphology and Parasitology, University of Veterinary Sciences Brno, Brno, Czechia., Hurník P; Laboratory of Molecular Morphogenesis, Institute of Animal Physiology and Genetics, Czech Academy of Sciences, Brno, Czechia.; Institute of Molecular and Clinical Pathology and Medical Genetics, University Hospital Ostrava, Ostrava, Czechia.; Institute of Molecular and Clinical Pathology and Medical Genetics, Faculty of Medicine, University of Ostrava, Ostrava, Czechia., Štembírek J; Laboratory of Molecular Morphogenesis, Institute of Animal Physiology and Genetics, Czech Academy of Sciences, Brno, Czechia.; Department of Maxillofacial Surgery, University Hospital Ostrava, Ostrava, Czechia., Buchtová M; Laboratory of Molecular Morphogenesis, Institute of Animal Physiology and Genetics, Czech Academy of Sciences, Brno, Czechia.; Department of Experimental Biology, Faculty of Science, Masaryk University, Brno, Czechia., Kolísková P; Laboratory of Molecular Morphogenesis, Institute of Animal Physiology and Genetics, Czech Academy of Sciences, Brno, Czechia.; Department of Experimental Biology, Faculty of Science, Masaryk University, Brno, Czechia.
Jazyk:	angličtina
Zdroj:	Frontiers in oncology [Front Oncol] 2024 Aug 21; Vol. 14, pp. 1413255. Date of Electronic Publication: 2024 Aug 21 (Print Publication: 2024).
DOI:	10.3389/fonc.2024.1413255
Abstrakt:	Squamous cell carcinoma (SCC) of the head and neck originates from the mucosal lining of the upper aerodigestive tract, including the lip, tongue, nasopharynx, oropharynx, larynx and hypopharynx. In this review, we summarise what is currently known about the potential function of primary cilia in the pathogenesis of this disease. As primary cilia represent a key cellular structure for signal transduction and are related to cell proliferation, an understanding of their role in carcinogenesis is necessary for the design of new treatment approaches. Here, we introduce cilia-related signalling in head and neck squamous cell carcinoma (HNSCC) and its possible association with HNSCC tumorigenesis. From this point of view, PDGF, EGF, Wnt and Hh signalling are discussed as all these pathways were found to be dysregulated in HNSCC. Moreover, we review the clinical potential of small molecules affecting primary cilia signalling to target squamous cell carcinoma of the head and neck area. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2024 Putnová, Putnová, Hurník, Štembírek, Buchtová and Kolísková.)
Databáze:	MEDLINE
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