Dangerous liaisons: Loss of keratinocyte control over melanocytes in melanomagenesis.

Autor: Green KJ; Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, USA.; Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, USA.; Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, USA., Pokorny J; Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, USA., Jarrell B; Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, USA.
Jazyk: angličtina
Zdroj: BioEssays : news and reviews in molecular, cellular and developmental biology [Bioessays] 2024 Nov; Vol. 46 (11), pp. e2400135. Date of Electronic Publication: 2024 Sep 04.
DOI: 10.1002/bies.202400135
Abstrakt: Melanomas arise from transformed melanocytes, positioned at the dermal-epidermal junction in the basal layer of the epidermis. Melanocytes are completely surrounded by keratinocyte neighbors, with which they communicate through direct contact and paracrine signaling to maintain normal growth control and homeostasis. UV radiation from sunlight reshapes this communication network to drive a protective tanning response. However, repeated rounds of sun exposure result in accumulation of mutations in melanocytes that have been considered as primary drivers of melanoma initiation and progression. It is now clear that mutations in melanocytes are not sufficient to drive tumor formation-the tumor environment plays a critical role. This review focuses on changes in melanocyte-keratinocyte communication that contribute to melanoma initiation and progression, with a particular focus on recent mechanistic insights that lay a foundation for developing new ways to intercept melanoma development.
(© 2024 The Author(s). BioEssays published by Wiley Periodicals LLC.)
Databáze: MEDLINE
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