Suction-Based Optical Coherence Elastography for the Biomechanical Characterization of Pathological Skin Conditions: A Pilot Study.

Autor: van Haasterecht L; LaserLab Amsterdam, Department of Physics and Astronomy, Faculty of Sciences Vrije Universiteit, Amsterdam, The Netherlands.; Amsterdam UMC, Location VUmc, Department of Plastic, Reconstructive and Hand Surgery, Amsterdam Movement Sciences, Amsterdam, The Netherlands.; Burn Center, Red Cross Hospital, Beverwijk, The Netherlands., Bartolini L; LaserLab Amsterdam, Department of Physics and Astronomy, Faculty of Sciences Vrije Universiteit, Amsterdam, The Netherlands., Louter JMI; Amsterdam UMC, Location VUmc, Department of Plastic, Reconstructive and Hand Surgery, Amsterdam Movement Sciences, Amsterdam, The Netherlands., González PJ; LaserLab Amsterdam, Department of Physics and Astronomy, Faculty of Sciences Vrije Universiteit, Amsterdam, The Netherlands., Niessen FB; Amsterdam UMC, Location VUmc, Department of Plastic, Reconstructive and Hand Surgery, Amsterdam Movement Sciences, Amsterdam, The Netherlands.; Scar Clinic, Amsterdam UMC Location VUmc, Amsterdam, The Netherlands.; Mittsu Institute, Amsterdam, The Netherlands., Iannuzzi D; LaserLab Amsterdam, Department of Physics and Astronomy, Faculty of Sciences Vrije Universiteit, Amsterdam, The Netherlands., Groot ML; LaserLab Amsterdam, Department of Physics and Astronomy, Faculty of Sciences Vrije Universiteit, Amsterdam, The Netherlands., van Zuijlen PPM; Amsterdam UMC, Location VUmc, Department of Plastic, Reconstructive and Hand Surgery, Amsterdam Movement Sciences, Amsterdam, The Netherlands.; Burn Center, Red Cross Hospital, Beverwijk, The Netherlands.; Pediatric Surgical Centre, Emma Children's Hospital, Amsterdam UMC Location University of Amsterdam, Amsterdam, The Netherlands.
Jazyk: angličtina
Zdroj: Journal of biophotonics [J Biophotonics] 2024 Nov; Vol. 17 (11), pp. e202300314. Date of Electronic Publication: 2024 Sep 04.
DOI: 10.1002/jbio.202300314
Abstrakt: Accurate characterization of mechanical properties is crucial in the evaluation of therapeutic effects for problematic skin conditions. A pilot study was carried out using a novel optical coherence elastography (OCE) device, combining mechanical characterization through suction-based deformation and imaging through optical coherence tomography. Using AI-assisted image segmentation and a power-law model, we were able to describe the mechanical behavior, comparing with measurements from the most commonly used commercial instrument (Cutometer) and subjective analyses of stiffness using the Patient and Observer Scar Assessment Scale. Twenty subjects were included with either keloids or hypertrophic scars. Measurements were fast and produced no discomfort. Mechanical and structural (epidermal thickness and rugosity) descriptors in pathologic skin conditions differed significantly from those in control tissue. We showed for the first time, the clinical feasibility of this novel suction-based OCE device in evaluating mechanical and structural properties in pathological skin conditions such as scars.
(© 2024 The Author(s). Journal of Biophotonics published by Wiley‐VCH GmbH.)
Databáze: MEDLINE
Externí odkaz: