Glutamate dynamics and BOLD response during OCD symptom provocation in the lateral occipital cortex: A 7 Tesla fMRI-fMRS study.

Autor: de Joode NT; Amsterdam UMC, Vrije Universiteit Amsterdam, Dept. Anatomy and Neurosciences, De Boelelaan 1117, Amsterdam, Netherlands; Amsterdam Neuroscience, Compulsivity Impulsivity Attention Program, Amsterdam, Netherlands. Electronic address: n.dejoode@amsterdamumc.nl., van den Heuvel OA; Amsterdam UMC, Vrije Universiteit Amsterdam, Dept. Anatomy and Neurosciences, De Boelelaan 1117, Amsterdam, Netherlands; Amsterdam UMC, Vrije Universiteit Amsterdam, Dept. Psychiatry, De Boelelaan 1117, Amsterdam, Netherlands; Amsterdam Neuroscience, Compulsivity Impulsivity Attention Program, Amsterdam, Netherlands., Koster M; Amsterdam UMC, Vrije Universiteit Amsterdam, Dept. Anatomy and Neurosciences, De Boelelaan 1117, Amsterdam, Netherlands; Amsterdam Neuroscience, Compulsivity Impulsivity Attention Program, Amsterdam, Netherlands., Clarke WT; Wellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK., van Balkom AJLM; Amsterdam UMC, Vrije Universiteit Amsterdam, Dept. Psychiatry, De Boelelaan 1117, Amsterdam, Netherlands; GGZ inGeest Specialised Mental Health Care, Amsterdam, Netherlands., Schrantee A; Amsterdam Neuroscience, Compulsivity Impulsivity Attention Program, Amsterdam, Netherlands; Amsterdam UMC, University of Amsterdam, Radiology and Nuclear Medicine, Meibergdreef 9, Amsterdam, Netherlands., Vriend C; Amsterdam UMC, Vrije Universiteit Amsterdam, Dept. Anatomy and Neurosciences, De Boelelaan 1117, Amsterdam, Netherlands; Amsterdam UMC, Vrije Universiteit Amsterdam, Dept. Psychiatry, De Boelelaan 1117, Amsterdam, Netherlands; Amsterdam Neuroscience, Compulsivity Impulsivity Attention Program, Amsterdam, Netherlands. Electronic address: c.vriend@amsterdamumc.nl.
Jazyk: angličtina
Zdroj: Journal of affective disorders [J Affect Disord] 2024 Dec 15; Vol. 367, pp. 416-425. Date of Electronic Publication: 2024 Sep 02.
DOI: 10.1016/j.jad.2024.08.216
Abstrakt: Obsessive-compulsive disorder (OCD) is linked with dysfunction in frontal-striatal, fronto-limbic, and visual brain regions. Research using proton magnetic resonance spectroscopy ( 1 H-MRS) suggests that altered neurometabolite levels, like glutamate, may contribute to this dysfunction. However, static neurometabolite levels in OCD patients have shown inconsistent results, likely due to previous studies' limited focus on neurometabolite dynamics. We employ functional MRS (fMRS) and functional magnetic resonance imaging (fMRI) to explore these dynamics and brain activation during OCD symptom provocation. We utilized a combined 7-tesla fMRI-fMRS setup to examine task-related BOLD response and glutamate changes in the lateral occipital cortex (LOC) of 30 OCD participants and 34 matched controls during an OCD-specific symptom provocation task. The study examined main effects and between-group differences in brain activation and glutamate levels during the task. A whole sample task-effects analysis on data meeting predefined quality criteria showed significant glutamate increases (n = 41 (22 OCD, 19 controls), mean change: 3.2 %, z = 3.75, p < .001) and task activation (n = 54 (26 OCD, 28 controls), p < .001) in the LOC during OCD blocks compared to neutral blocks. However, no differences in task-induced glutamate dynamics or activation between groups were found, nor a correlation between glutamate levels and task activation. We were able to measure task-induced increases in glutamate and BOLD levels, emphasizing its feasibility for OCD research. The absence of group differences highlights the need for further exploration to discern to what extent neurometabolite dynamics differ between OCD patients and controls. Once established, future studies can use pre-post intervention fMRS-fMRI to probe the effects of therapies modulating glutamate pathways in OCD.
Competing Interests: Declaration of competing interest The other authors report no biomedical financial interests or potential conflicts of interest.
(Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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