Quantification of respiratory sinus arrhythmia in control dogs and in dogs with various severity classes of myxomatous mitral valve disease.

Autor: Baisan RA; Clinic Department, Faculty of Veterinary Medicine, Iași University of Life Sciences 'Ion Ionescu de la Brad', Mihail Sadoveanu No 8, 700489, Romania. Electronic address: andrei.baisan@iuls.ro., Turcu CA; Clinic Department, Faculty of Veterinary Medicine, Iași University of Life Sciences 'Ion Ionescu de la Brad', Mihail Sadoveanu No 8, 700489, Romania., Bilboc LM; Clinic Department, Faculty of Veterinary Medicine, Iași University of Life Sciences 'Ion Ionescu de la Brad', Mihail Sadoveanu No 8, 700489, Romania., Maftei MC; Clinic Department, Faculty of Veterinary Medicine, Iași University of Life Sciences 'Ion Ionescu de la Brad', Mihail Sadoveanu No 8, 700489, Romania., Vulpe V; Clinic Department, Faculty of Veterinary Medicine, Iași University of Life Sciences 'Ion Ionescu de la Brad', Mihail Sadoveanu No 8, 700489, Romania., Ohad DG; Cardiology Service, Veterinary Teaching Hospital, Koret School of Veterinary Medicine, Robert H. Smith Faculty of Agriculture, Food and Environment, Hebrew University of Jerusalem, Israel, P.O. Box 12, Rehovot, 76100, Israel.
Jazyk: angličtina
Zdroj: Journal of veterinary cardiology : the official journal of the European Society of Veterinary Cardiology [J Vet Cardiol] 2024 Oct; Vol. 55, pp. 48-56. Date of Electronic Publication: 2024 Aug 12.
DOI: 10.1016/j.jvc.2024.08.001
Abstrakt: Introduction: Loss of respiratory sinus arrhythmia (RSA) is a negative prognostic factor in dogs with myxomatous mitral valve disease (MMVD). The aim of this study was to calculate the percentage (%) of RSA in healthy dogs and dogs in various MMVD classes.
Animals: Control and MMVD dogs were prospectively included in the study.
Materials and Methods: Respiratory sinus arrhythmia was calculated from a dual channel electrocardiography and breathing curve recording using the peak-to-trough method, in percent of the average heart rate.
Results: One hundred and forty-nine dogs were studied, including 24 control and 125 MMVD dogs of different severity classes. An overall %RSA decrease was documented with increasing disease severity up to the Ca class along with a relative %RSA increase in the Cc class. The %RSA magnitude differed between B2 and Ca (P<0.001), and between Ca and Cc (P = 0.001) groups, respectively. The %RSA showed a medium negative correlation with the La:Ao ratio (r2 = -0.568, P<0.001) and with the E-wave velocity (r2 = -0.561, P<0.001).
Discussions: A decrease in %RSA was shown with increased disease severity up to acute congestive heart failure (CHF). Dogs receiving cardiac therapy leading to stabilized CHF might restore their ability to exhibit RSA, often revealing a higher %RSA compared to those in acute CHF.
Study Limitations: Low number of respiratory cycles for analysis. Therapy effect not evaluated.
Conclusions: The findings of this study can serve as the basis for future risk stratification and carry the potential of proving an additional clinical marker for diagnostic and therapeutic decisions making when managing MMVD dogs.
Competing Interests: Conflicts of Interest Statement The authors do not have any conflicts of interest to disclose.
(Copyright © 2024 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: