Immunological roles for resistin and related adipokines in obesity-associated tumors.

Autor: Zhang J; Department of Integration of Chinese and Western Medicine, School of Basic Medical Sciences, Peking University, Beijing 100191, China., Lu E; Department of Gynecology, the First Affiliated Hospital of China Medical University, Shenyang, Liaoning 110001, China., Deng L; Department of Gynecology, the First Affiliated Hospital of China Medical University, Shenyang, Liaoning 110001, China., Zhu Y; Department of Integration of Chinese and Western Medicine, School of Basic Medical Sciences, Peking University, Beijing 100191, China., Lu X; Department of Integration of Chinese and Western Medicine, School of Basic Medical Sciences, Peking University, Beijing 100191, China., Li X; School of Nursing, Beijing University of Chinese Medicine, Beijing 100029, China., Li F; Department of Gynecology, the First Affiliated Hospital of China Medical University, Shenyang, Liaoning 110001, China., Yan Y; Department of Gynecology, the First Affiliated Hospital of China Medical University, Shenyang, Liaoning 110001, China., Han JY; Department of Integration of Chinese and Western Medicine, School of Basic Medical Sciences, Peking University, Beijing 100191, China., Li Y; Department of Integration of Chinese and Western Medicine, School of Basic Medical Sciences, Peking University, Beijing 100191, China. Electronic address: yinli@bjmu.edu.cn., Zhang Y; Department of Gynecology, the First Affiliated Hospital of China Medical University, Shenyang, Liaoning 110001, China. Electronic address: syzi@163.com.
Jazyk: angličtina
Zdroj: International immunopharmacology [Int Immunopharmacol] 2024 Dec 05; Vol. 142 (Pt A), pp. 112911. Date of Electronic Publication: 2024 Sep 03.
DOI: 10.1016/j.intimp.2024.112911
Abstrakt: Rationale Obesity is an independent risk factor for the occurrence and development of tumors. Obesity is influenced by signaling of adipokines, which are secreted factors from adipocytes and resident immune cells within adipose tissues that mediate lipid metabolism. More recently, adipokines have been implicated in chronic inflammation as well as in tumor formation and growth. Among them, resistin has received increasing attention in research related to the growth and expansion of solid tumors and hematological cancers through various signaling pathways. Objective and findings We reviewed the physiological, biochemical, and immune functions of adipose tissue, with a focus on the structure and expression of resistin and adipokines within multiple adipose cell types, their signaling pathways and putative effects on tumor cells, as well as their in vivo regulation. Current evidence indicates that adipokines such as resistin act as pro-inflammatory factors to stimulate immune cells which, in turn, promotes tumor angiogenesis, connective tissue proliferation, and matrix fibrosis. Concurrently, in states of metabolic dysfunction and lipotoxicity in obese individuals, the numbers and functions of immune cells are compromised, leading to an immunosuppressive environment that fosters tumor cell survival and weak cancer immune monitoring. Conclusion Adipokines such as resistin are important to the development of obesity-related tumors. Clarifying the roles for obesity-related factors in immune regulation and tumor progression may lead to the discovery of novel anti-tumor strategies for targeting obesity factors such as resistin to limit tumor growth and manage obesity, or both.
(Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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