Reliability and validity of a newly developed PANDAS/PANS questionnaire.
| Autor: | Bleibach A; Department of Paediatrics and Adolescents Medicine, Copenhagen University Hospital - Herlev and Gentofte, Herlev, Denmark. Electronic address: nanette.marinette.monique.debes@regionh.dk., Sørensen CB; Department of Paediatrics and Adolescents Medicine, Copenhagen University Hospital - Herlev and Gentofte, Herlev, Denmark., Skov L; Department of Paediatrics and Adolescents Medicine, Copenhagen University Hospital - Herlev and Gentofte, Herlev, Denmark., Christensen KB; Section of Biostatistics, Department of Public Health, University of Copenhagen, Copenhagen, Denmark., Debes NM; Department of Paediatrics and Adolescents Medicine, Copenhagen University Hospital - Herlev and Gentofte, Herlev, Denmark; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark. |
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| Jazyk: | angličtina |
| Zdroj: | European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society [Eur J Paediatr Neurol] 2024 Sep; Vol. 52, pp. 109-130. Date of Electronic Publication: 2024 Jul 15. |
| DOI: | 10.1016/j.ejpn.2024.07.008 |
| Abstrakt: | Objective: This study aimed to examine the reliability and validity of a newly developed questionnaire for Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal infections (PANDAS) and Pediatric Acute-onset Neuropsychiatric Syndrome (PANS). The aim was to contribute to future standardisation of screening methods for symptoms and comorbidity, as well as the measurement of symptom severity, daily life impairment, and treatment effectiveness in individuals diagnosed with PANDAS/PANS. Methods: 27 items from the PANDAS/PANS questionnaire concerning symptoms and comorbidities associated with PANDAS/PANS were divided into ten domains. To assess the external validity, 119 PANDAS/PANS questionnaires from a cohort of 65 children with PANDAS/PANS were correlated with three well-known validated questionnaires: the Children's Yale-Brown Obsessive-Compulsive Scale (CY-BOCS), Attention Deficit Hyperactivity Disorder Rating Scale (ADHD-RS), and the Strengths and Difficulties Questionnaire (SDQ). The internal validity of the PANDAS/PANS questionnaire was assessed by correlating the PANDAS/PANS items with the domains. Results: Internal consistency of the PANDAS/PANS questionnaire was high, measuring moderate to very strong correlations. The external correlations for the PANDAS/PANS questionnaire showed a higher correlation with the ADHD-RS and CY-BOCS (r Conclusion: The validity and clinical feasibility of the PANDAS/PANS questionnaire were confirmed as an effective tool for screening symptoms, assessing symptom severity, and evaluating comorbidity and daily life impairment in individuals with PANDAS/PANS. These findings can potentially enhance the management of PANDAS/PANS patients in both clinical and research settings. Competing Interests: Declaration of competing interest None of the authors have stated any conflicts of interest. (Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.) |
| Databáze: | MEDLINE |
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