Farmed fur animals harbour viruses with zoonotic spillover potential.

Autor: Zhao J; Department of Epidemiology, School of Public Health, Shanghai Institute of Infectious Disease and Biosecurity, Fudan University, Shanghai, China., Wan W; Department of Epidemiology, School of Public Health, Shanghai Institute of Infectious Disease and Biosecurity, Fudan University, Shanghai, China., Yu K; Department of Epidemiology, School of Public Health, Shanghai Institute of Infectious Disease and Biosecurity, Fudan University, Shanghai, China.; State Key Laboratory of Natural Medicines, School of Pharmacy, China Pharmaceutical University, Nanjing, China., Lemey P; Department of Microbiology, Immunology and Transplantation, Rega Institute, Laboratory for Clinical and Epidemiological Virology, KU Leuven, Leuven, Belgium., Pettersson JH; Clinical Microbiology, Department of Medical Sciences, University of Uppsala, Uppsala, Sweden.; Clinical Microbiology and Hospital Hygiene, Uppsala University Hospital, Uppsala, Sweden.; Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Victoria, Australia., Bi Y; CAS Key Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences (CAS), Beijing, China., Lu M; Department of Epidemiology, School of Public Health, Shanghai Institute of Infectious Disease and Biosecurity, Fudan University, Shanghai, China., Li X; Jiangsu Engineering Laboratory of Animal Immunology, Institute of Immunology, College of Veterinary Medicine, Academy for Advanced Interdisciplinary Studies, Nanjing Agricultural University, Nanjing, China., Chen Z; Department of Epidemiology, School of Public Health, Shanghai Institute of Infectious Disease and Biosecurity, Fudan University, Shanghai, China., Zheng M; Jiangsu Engineering Laboratory of Animal Immunology, Institute of Immunology, College of Veterinary Medicine, Academy for Advanced Interdisciplinary Studies, Nanjing Agricultural University, Nanjing, China., Yan G; State Key Laboratory of Natural Medicines, School of Pharmacy, China Pharmaceutical University, Nanjing, China., Dai J; State Key Laboratory of Natural Medicines, School of Pharmacy, China Pharmaceutical University, Nanjing, China., Li Y; Department of Epidemiology, School of Public Health, Shanghai Institute of Infectious Disease and Biosecurity, Fudan University, Shanghai, China., Haerheng A; Department of Epidemiology, School of Public Health, Shanghai Institute of Infectious Disease and Biosecurity, Fudan University, Shanghai, China., He N; Department of Epidemiology, School of Public Health, Shanghai Institute of Infectious Disease and Biosecurity, Fudan University, Shanghai, China., Tu C; Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun, China., Suchard MA; Department of Biostatistics, Fielding School of Public Health, and Departments of Biomathematics and Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA., Holmes EC; School of Medical Sciences, The University of Sydney, Sydney, New South Wales, Australia.; Laboratory of Data Discovery for Health Limited, Hong Kong SAR, China., He WT; State Key Laboratory of Natural Medicines, School of Pharmacy, China Pharmaceutical University, Nanjing, China. hewt@cpu.edu.cn., Su S; Department of Epidemiology, School of Public Health, Shanghai Institute of Infectious Disease and Biosecurity, Fudan University, Shanghai, China. shuosu@fudan.edu.cn.
Jazyk: angličtina
Zdroj: Nature [Nature] 2024 Oct; Vol. 634 (8032), pp. 228-233. Date of Electronic Publication: 2024 Sep 04.
DOI: 10.1038/s41586-024-07901-3
Abstrakt: Animals such as raccoon dogs, mink and muskrats are farmed for fur and are sometimes used as food or medicinal products 1,2 , yet they are also potential reservoirs of emerging pathogens 3 . Here we performed single-sample metatranscriptomic sequencing of internal tissues from 461 individual fur animals that were found dead due to disease. We characterized 125 virus species, including 36 that were novel and 39 at potentially high risk of cross-species transmission, including zoonotic spillover. Notably, we identified seven species of coronaviruses, expanding their known host range, and documented the cross-species transmission of a novel canine respiratory coronavirus to raccoon dogs and of bat HKU5-like coronaviruses to mink, present at a high abundance in lung tissues. Three subtypes of influenza A virus-H1N2, H5N6 and H6N2-were detected in the lungs of guinea pig, mink and muskrat, respectively. Multiple known zoonotic viruses, such as Japanese encephalitis virus and mammalian orthoreovirus 4,5 , were detected in guinea pigs. Raccoon dogs and mink carried the highest number of potentially high-risk viruses, while viruses from the Coronaviridae, Paramyxoviridae and Sedoreoviridae families commonly infected multiple hosts. These data also reveal potential virus transmission between farmed animals and wild animals, and from humans to farmed animals, indicating that fur farming represents an important transmission hub for viral zoonoses.
(© 2024. The Author(s), under exclusive licence to Springer Nature Limited.)
Databáze: MEDLINE
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