Glycated albumin may have a complementary role to glycated hemoglobin in glucose monitoring in childhood acute leukemia.

Autor:	Sim SY; Department of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Korea., Park SJ; Department of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Korea., Yoo JW; Department of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Korea., Kim S; Department of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Korea., Lee JW; Department of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Korea., Chung NG; Department of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Korea., Cho B; Department of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Korea., Suh BK; Department of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Korea., Ahn MB; Department of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Jazyk:	angličtina
Zdroj:	Annals of pediatric endocrinology & metabolism [Ann Pediatr Endocrinol Metab] 2024 Aug; Vol. 29 (4), pp. 266-275. Date of Electronic Publication: 2024 Aug 31.
DOI:	10.6065/apem.2346100.050
Abstrakt:	Purpose: Glycated hemoglobin (HbA1c) as a glycemic index may have limited value in pediatric patients with acute leukemia as they often present with anemia and/or pancytopenia. To address this issue, we evaluated the usefulness of glycated albumin (GA) as a glycemic monitoring index in pediatric patients with acute leukemia. Methods: Medical records of 25 patients with type 2 diabetes mellitus (T2DM), 63 patients with acute leukemia, and 115 healthy children from Seoul St. Mary's Hospital, The Catholic University of Korea, were retrospectively investigated for serum GA, HbA1c, and fasting blood glucose (FBG) levels, along with demographic data. Results: GA, HbA1c, and FBG levels did not differ between the control and acute leukemia groups. In the T2DM group, positive correlations were observed among GA, HbA1c, and FBG (P<0.01). Although GA level was not associated with the HbA1c level in the control group, GA and HbA1c levels showed a positive correlation in the acute leukemia group (P=0.045). Regression analysis revealed GA and HbA1c levels to be positively correlated in the acute leukemia and T2DM groups even after adjusting for age, sex, and body mass index z-score (P=0.007, P<0.01). Conclusion: GA may be a useful complementary parameter to HbA1c for glycemic monitoring in pediatric patients with acute leukemia, similar to its use in patients with T2DM.
Databáze:	MEDLINE
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