Polyprenylated Benzophenones from Brazilian Red Propolis: Analytical Characterization and Anticancer Activity.

Autor: Pires LM; Unifran, Laboratory of Genetics and Molecular Biology, Av. Dr. Armando Salles de Oliveira, 201, Franca, BRAZIL., Santos MFC; Unifran, Natural Products Group, Av. Dr. Armando Salles de Oliveira, 201, Franca, BRAZIL., Figueiredo LR; Unifran, Laboratory of Genetics and Molecular Biology, Av. Dr. Armando Salles de Oliveira, 201, Franca, BRAZIL., Faleiros R; Unifran, Laboratory of Genetics and Molecular Biology, Av. Dr. Armando Salles de Oliveira, 201, Franca, BRAZIL., Badoco FR; Unifran, Natural Products Group, Av. Dr. Armando Salles de Oliveira, 201, Franca, BRAZIL., Silva KB; Unifran, Laboratory of Genetics and Molecular Biology, Av. Dr. Armando Salles de Oliveira, 201, Franca, BRAZIL., Ambrósio SR; Unifran, Natural Products Group, Av. Dr. Armando Salles de Oliveira, 201, Franca, BRAZIL., Bastos JK; University of Sao Paulo, School of Pharmaceutical Sciences of Ribeirão Preto, Av. Prof. Dr. Zeferino Vaz, Ribeirão Preto, BRAZIL., Santos RAA; Universidade de Franca, NUCLEO DE PESQUISA EM CIÊNCIAS EXATAS E TECNOLÓGICAS, Av. Dr. Armando Salles de Oliveira, 201, Laboratorio de Genetica e Biologia Molecular, 14404600, Franca, BRAZIL., Veneziani RCS; Unifran, Natural Products Group, Av. Dr. Armando Salles de Oliveira, 201, Franca, BRAZIL.
Jazyk: angličtina
Zdroj: Chemistry & biodiversity [Chem Biodivers] 2024 Sep 04, pp. e202401288. Date of Electronic Publication: 2024 Sep 04.
DOI: 10.1002/cbdv.202401288
Abstrakt: The present work describes the extraction of a polyprenylated benzophenone-rich extract from Brazilian red propolis (ERPB), the development and validation of an RP-HPLC-UV method to characterize it, and its evaluation against breast cancer cell lines MCF-7 and MDA-MB-231, as well as the normal counterpart MCF-10A. A mixture of gutifferone E and xanthochymol (1+2), and isolated oblongifolin B (3) were used as chemical standards for ERPB and were also evaluated. The concentrations of 1+2 and 3 corresponded to 16.68% and 42.25% of the total content of the extract, respectively, and the validation parameters evaluated were satisfactorily met. The cytotoxic effects of ERPB were assessed, and the obtained IC50 values were 19.58 μg/mL (MCF-10A), 11.56 μg/mL (MCF-7), and 5.22 μg/mL (MDA-MB-231). In conclusion, ERPB exhibits promising cytotoxic effects on the tested breast cell lines. However, further investigation to elucidate its potential therapeutic applications and safety profile should be conducted.
(© 2024 Wiley‐VCH GmbH.)
Databáze: MEDLINE
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