Urinary iodine clearance after iodinated contrast administration to healthy cats.

Autor: Allegrini G; Animal Cancer Centre, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada., Poirier VJ; Animal Cancer Centre, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada., Pezzali JG; Department of Animal Biosciences, Ontario Agricultural College, University of Guelph, Guelph, Ontario, Canada., Beaufrère HH; Department of Veterinary Medicine and Epidemiology, University of California Davis, School of Veterinary Medicine, Davis, California, USA., Shoveller AK; Department of Animal Biosciences, Ontario Agricultural College, University of Guelph, Guelph, Ontario, Canada., Kopke MA; Veterinary Nutrition Group, Sydney, New South Wales, Australia., Beeler-Marfisi J; Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada.
Jazyk: angličtina
Zdroj: Journal of veterinary internal medicine [J Vet Intern Med] 2024 Sep-Oct; Vol. 38 (5), pp. 2556-2560. Date of Electronic Publication: 2024 Sep 04.
DOI: 10.1111/jvim.17172
Abstrakt: Background: Exogenous iodine interferes with the uptake of radioactive iodine ( 131 I) by the thyroid gland. This has potential implications for the treatment of cats with hyperthyroidism that have recently undergone computed tomography (CT) with IV administration of iodinated contrast medium (ICM).
Hypothesis: To determine the time to normalize urinary iodine clearance after administration of ICM. We hypothesized that it would require 4 weeks for urinary iodine concentration (UIC) to decrease to baseline after IV administration of ICM.
Animals: Ten healthy adult neutered male cats.
Methods: All cats were sedated and received Iopamidol at a dose of 2 mL/kg (600 mg/kg). Urinary iodine and creatinine concentrations were measured before administration of Iopamidol and on days 1, 2, 3, 7, 10 and weeks 2 to 6 after administration. The urinary iodine-to-creatinine ratio (UICR) was calculated. Outcome variables were modeled using a linear mixed-effects model.
Results: Urinary iodine concentration increased 37- to 884-fold on Day 1 after ICM injection and returned to baseline during Week 2. Compared with baseline, UIC was significantly increased for Days 1 to 7 (all P < .001); UC was significantly lower for Days 1 to 10 (all P < .03); and UICR was significantly increased from Days 1 to 10 (all P < .001, except Day 10 P = .05).
Conclusions: Urinary clearance of iodine after IV administration of ICM requires 10 days to return to baseline in healthy cats. A 2-week interval between the iodinated contrast study and 131 I treatment could be appropriate but needs to be confirmed in hyperthyroid cats.
(© 2024 The Author(s). Journal of Veterinary Internal Medicine published by Wiley Periodicals LLC on behalf of American College of Veterinary Internal Medicine.)
Databáze: MEDLINE
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